Güell A, Géraud G, Jauzac P, Victor G, Arné-Bès M C
J Cereb Blood Flow Metab. 1982;2(2):255-7. doi: 10.1038/jcbfm.1982.26.
In baboons, the intravenous administration of piribedil, a dopaminergic agonist, was associated with marked dose dependent increases in CBF and cerebral oxygen consumption. We have studied the effects of piribedil on CBF in 20 normal, human volunteers of comparable ages. Ten received 0.1 mg/kg piribedil intravenously for 30 min; the other ten received 0.2 mg/kg. In the first group, CBF did not vary significantly, in the second group, there was a mean increase in CBF of 21.8% (p less than or equal to 0.005). In man, as in animals, piribedil provokes an increase of CBF.
在狒狒中，静脉注射多巴胺能激动剂吡贝地尔与脑血流量（CBF）和脑氧耗量显著的剂量依赖性增加相关。我们研究了吡贝地尔对20名年龄相仿的正常人类志愿者脑血流量的影响。其中10人静脉注射0.1mg/kg吡贝地尔，持续30分钟；另外10人注射0.2mg/kg。第一组中，脑血流量无显著变化；第二组中，脑血流量平均增加了21.8%（p≤0.005）。在人类中，如同在动物中一样，吡贝地尔可引起脑血流量增加。
