Okaru Alex O, Lachenmeier Dirk W
Department of Pharmaceutical Chemistry, University of Nairobi, P.O. Box 19676-00202, Nairobi, Kenya.
Chemisches und Veterinäruntersuchungsamt (CVUA) Karlsruhe, Weissenburger Strasse 3, 76187 Karlsruhe, Germany.
Toxics. 2017 Mar 11;5(1):9. doi: 10.3390/toxics5010009.
For decades, compounds present in foods and beverages have been implicated in the etiology of human cancers. The World Health Organization (WHO) International Agency for Research on Cancer (IARC) continues to classify such agents regarding their potential carcinogenicity in humans based on new evidence from animal and human studies. Furfuryl alcohol and β-myrcene are potential human carcinogens due to be evaluated. The major source of furfuryl alcohol in foods is thermal processing and ageing of alcoholic beverages, while β-myrcene occurs naturally as a constituent of the essential oils of plants such as hops, lemongrass, and derived products. This study aimed to summarize the occurrence of furfuryl alcohol and β-myrcene in foods and beverages using literature review data. Additionally, results of furfuryl alcohol occurrence from our own nuclear magnetic resonance (NMR) analysis are included. The highest content of furfuryl alcohol was found in coffee beans (>100 mg/kg) and in some fish products (about 10 mg/kg), while among beverages, wines contained between 1 and 10 mg/L, with 8 mg/L in pineapple juice. The content of β-myrcene was highest in hops. In conclusion, the data about the occurrence of the two agents is currently judged as insufficient for exposure and risk assessment. The results of this study point out the food and beverage groups that may be considered for future monitoring of furfuryl alcohol and β-myrcene.
几十年来,食品和饮料中的化合物一直被认为与人类癌症的病因有关。世界卫生组织(WHO)国际癌症研究机构(IARC)继续根据动物和人体研究的新证据,对这类物质在人类中的潜在致癌性进行分类。糠醇和β-月桂烯是有待评估的潜在人类致癌物。食品中糠醇的主要来源是酒精饮料的热处理和陈化,而β-月桂烯作为啤酒花、柠檬草等植物精油及其衍生产品的成分天然存在。本研究旨在利用文献综述数据总结食品和饮料中糠醇和β-月桂烯的含量。此外,还包括我们自己的核磁共振(NMR)分析得出的糠醇含量结果。咖啡豆中糠醇含量最高(>100毫克/千克),一些鱼类产品中含量约为10毫克/千克,而在饮料中,葡萄酒中糠醇含量为1至10毫克/升,菠萝汁中为8毫克/升。β-月桂烯含量在啤酒花中最高。总之,目前认为关于这两种物质含量的数据不足以进行暴露和风险评估。本研究结果指出了未来可能需要监测糠醇和β-月桂烯的食品和饮料类别。