Nicholson A N, Stone B M
Eur J Clin Pharmacol. 1986;30(1):27-32. doi: 10.1007/BF00614191.
The central effects of various antihistamines were studied using a variety of tests of performance, including visuo-motor co-ordination and dynamic visual acuity, as well as paper and pencil tests and critical flicker fusion. The possible relationship between performance and sedation was also studied using digit symbol substitution and latencies to drowsy sleep. There was high degree of correlation between drowsiness, as indicated by the relative ease with which individuals fell asleep over the day, and impaired performance, but it was not possible to establish the relationship for each time of the day. These findings lend some support to the suggestion that impaired performance with antihistamines may be a non-specific effect of sedation.
使用多种性能测试方法，包括视觉运动协调和动态视敏度测试，以及纸笔测试和临界闪烁融合测试，研究了各种抗组胺药的中枢效应。还使用数字符号替换和困倦睡眠潜伏期研究了性能与镇静之间的可能关系。一天中个体入睡的相对难易程度所表明的嗜睡与性能受损之间存在高度相关性，但无法确定一天中每个时间段的这种关系。这些发现为以下观点提供了一些支持，即抗组胺药导致的性能受损可能是镇静的非特异性效应。
