Qin Jie, Lu Chun
Key Laboratory of Pathogen Biology (Jiangsu Province), Nanjing Medical University, Nanjing, People's Republic of China.
Department of Microbiology, Nanjing Medical University, Nanjing, 210029, People's Republic of China.
Adv Exp Med Biol. 2017;1018:237-251. doi: 10.1007/978-981-10-5765-6_15.
Kaposi's sarcoma-associated herpesvirus (KSHV), namely, human herpesvirus 8 (HHV-8), is considered as the pathogen of Kaposi's sarcoma (KS), the most frequent cancer in untreated HIV-infected individuals. Patients infected with HIV have a much higher possibility developing KS than average individual. Researchers have found that HIV, which functions as a cofactor of KS, contributes a lot to the development of KS. In this article, we will give a brief introduction of KS and KSHV and how the interaction between KSHV and HIV contributes to the development of KS. Also we will take a glance at the development of treatment in KS, especially AIDS-KS.
卡波西肉瘤相关疱疹病毒（KSHV），即人类疱疹病毒8型（HHV-8），被认为是卡波西肉瘤（KS）的病原体，卡波西肉瘤是未接受治疗的HIV感染者中最常见的癌症。感染HIV的患者患KS的可能性比普通人高得多。研究人员发现，HIV作为KS的辅助因子，对KS的发展起了很大作用。在本文中，我们将简要介绍KS和KSHV，以及KSHV与HIV之间的相互作用如何促进KS的发展。我们还将简要介绍KS治疗方法的发展，尤其是艾滋病相关卡波西肉瘤（AIDS-KS）的治疗方法。
