Tonkiss J, Morris R G, Rawlins J N
University of Oxford, Department of Experimental Psychology, UK.
Exp Brain Res. 1988;73(1):181-8. doi: 10.1007/BF00279671.
Rats were trained to lever press on a differential reinforcement of low rates (DRL-18 s) schedule. They were then allocated to four treatment groups. These were: hippocampal aspiration lesions [HIPP]; implantation of osmotic minipumps for intraventricular infusion of either (a) the NMDA receptor antagonist 30 mM D, L-2-amino-5-phosphonopentanoic acid [AP5] or (b) vehicle [VEH]; and an unoperated control group [UNOP]. In subsequent DRL testing, the HIPP group showed a profound and enduring loss of efficiency, resulting from an increased tendency to respond too early; the AP5 group showed a qualitatively similar, but less severe, impairment followed by full recovery once the minipumps had expired; the VEH and UNOP groups both maintained their pre-operative levels of efficiency. We conclude that AP5 infusion disrupts temporary memory storage in the hippocampus, and that the hippocampus is concerned with the retention of memories outside the purely spatial domain.
大鼠被训练在低速率差异强化（DRL-18秒）的实验安排下按压杠杆。然后将它们分为四个治疗组。分别是：海马体抽吸损伤组[HIPP]；植入渗透微型泵用于脑室内输注（a）NMDA受体拮抗剂30 mM D，L-2-氨基-5-磷酸戊酸[AP5]或（b）载体[VEH]；以及一个未手术的对照组[UNOP]。在随后的DRL测试中，HIPP组显示出效率的严重且持久的下降，这是由于过早做出反应的倾向增加所致；AP5组表现出定性相似但程度较轻的损伤，一旦微型泵失效后完全恢复；VEH组和UNOP组都保持了术前的效率水平。我们得出结论，输注AP5会破坏海马体中的临时记忆存储，并且海马体与纯粹空间领域之外的记忆保留有关。
