Kawahito Koji, Kimura Naoyuki, Yamaguchi Atsushi, Aizawa Kei, Misawa Yoshio, Adachi Hideo
Division of Cardiovascular Surgery, Jichi Medical University School of Medicine, Tochigi, Japan.
Department of Cardiovascular Surgery, Saitama Medical Center, Jichi Medical University School of Medicine, Saitama, Japan.
Ann Thorac Surg. 2018 Jan;105(1):137-143. doi: 10.1016/j.athoracsur.2017.06.057. Epub 2017 Oct 17.
Although surgical outcomes of acute type A aortic dissection (ATAAD) have improved, it is still a high-risk procedure for octogenarians. This study analyzed early and late outcomes of surgical repair of ATAAD among octogenarians.
From 1990 through 2016, 1,260 consecutive patients with ATAAD were emergently admitted to Jichi Medical University Hospitals. Of them, 1,026 patients who underwent emergency surgery for ATAAD within 48 hours of symptom onset were included in this retrospective study. Of these, 112 were aged 80 years or more (mean, 83.1 ± 2.7) and formed the octogenarian group; and 914 were aged less than 80 years (mean, 62.0 ± 11.4) and formed the control group. Early and late outcomes were compared.
The inhospital mortality rate was 6.3% for the octogenarian group and 7.4% for the control group (p = 0.85). No significant difference was observed in the causes of hospital death. Although the overall postoperative complication rate was not different (24.1% versus 23.0%), pneumonia was more frequent among octogenarians (p = 0.03). Multivariate analysis of hospital mortality did not indicate age 80 years or more as a risk factor. Overall postoperative survival for the octogenarian group was 84.6%, 70.5%, and 57.1% at 1, 3, and 5 years, respectively. For the control group, the rates were 89.1%, 85.6%, and 82.1%, respectively. Pneumonia and decrepitude were the major causes of remote death for the octogenarian group.
No significant difference in the hospital mortality rate or the complication rate was observed between the groups. Emergency surgery for ATAAD in octogenarians could be performed with the same low risk observed for younger patients.
尽管急性A型主动脉夹层(ATAAD)的手术效果有所改善,但对于八旬老人来说,这仍是一项高风险手术。本研究分析了八旬老人ATAAD手术修复的早期和晚期结果。
1990年至2016年期间,1260例连续的ATAAD患者紧急入住筑波大学附属医院。其中,1026例在症状出现后48小时内接受ATAAD急诊手术的患者纳入本回顾性研究。其中,112例年龄在80岁及以上(平均83.1±2.7岁),组成八旬老人组;914例年龄小于80岁(平均62.0±11.4岁),组成对照组。比较早期和晚期结果。
八旬老人组的住院死亡率为6.3%,对照组为7.4%(p = 0.85)。医院死亡原因无显著差异。尽管总体术后并发症发生率无差异(24.1%对23.0%),但八旬老人肺炎更常见(p = 0.03)。住院死亡率的多因素分析未表明80岁及以上年龄是危险因素。八旬老人组术后1年、3年和5年的总体生存率分别为84.6%、70.5%和57.1%。对照组的相应比率分别为89.1%、85.6%和82.1%。肺炎和衰老为八旬老人组远期死亡的主要原因。
两组间住院死亡率或并发症发生率无显著差异。八旬老人ATAAD急诊手术的风险与年轻患者相同,可以进行。