Vanderbilt University Medical Center, Nashville, TN, United States.
Vanderbilt University Medical Center, Nashville, TN, United States; Vanderbilt University School of Medicine, Vanderbilt University, Nashville, TN, United States; Vanderbilt University, Nashville, TN, United States; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, United States; Veterans Affairs Tennessee Valley HealthCare System, Nashville, TN, United States.
Adv Cancer Res. 2017;136:49-83. doi: 10.1016/bs.acr.2017.08.002.
Selenium is a micronutrient essential to human health and has long been associated with cancer prevention. Functionally, these effects are thought to be mediated by a class of selenium-containing proteins known as selenoproteins. Indeed, many selenoproteins have antioxidant activity which can attenuate cancer development by minimizing oxidative insult and resultant DNA damage. However, oxidative stress is increasingly being recognized for its "double-edged sword" effect in tumorigenesis, whereby it can mediate both negative and positive effects on tumor growth depending on the cellular context. In addition to their roles in redox homeostasis, recent work has also implicated selenoproteins in key oncogenic and tumor-suppressive pathways. Together, these data suggest that the overall contribution of selenoproteins to tumorigenesis is complicated and may be affected by a variety of factors. In this review, we discuss what is currently known about selenoproteins in tumorigenesis with a focus on their contextual roles in cancer development, growth, and progression.
硒是一种对人类健康至关重要的微量元素，长期以来一直与癌症预防有关。从功能上讲，这些作用被认为是由一类被称为硒蛋白的含硒蛋白介导的。事实上，许多硒蛋白具有抗氧化活性，通过最小化氧化损伤和由此产生的 DNA 损伤，可抑制癌症的发展。然而，氧化应激在肿瘤发生中的“双刃剑”效应越来越受到关注，根据细胞环境的不同，它可以对肿瘤生长产生负面和正面影响。除了在氧化还原稳态中的作用外，最近的研究还表明硒蛋白参与了关键的致癌和肿瘤抑制途径。这些数据表明，硒蛋白对肿瘤发生的总体贡献是复杂的，可能受到多种因素的影响。在这篇综述中，我们讨论了目前已知的硒蛋白在肿瘤发生中的作用，重点是它们在癌症发展、生长和进展中的背景作用。
