Donovan Lucas M, Rueschman Michael, Weng Jia, Basu Nisha, Dudley Katherine A, Bakker Jessie P, Wang Rui, Bertisch Suzanne M, Patel Sanjay R
University of Washington, 1959 NE Pacific St, Seattle, WA 98195, United States.
Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, United States.
Diabetes Res Clin Pract. 2017 Dec;134:145-152. doi: 10.1016/j.diabres.2017.10.013. Epub 2017 Oct 18.
As recommended by current guidelines, we tested the acceptability and impact of screening patients with type 2 diabetes for obstructive sleep apnea (OSA).
In a large urban primary care practice, we instituted a telephone-based OSA screening program using a validated tool (STOP-BANG) in patients with type 2 diabetes. Patients identified as high risk were referred for diagnostic sleep testing, and those diagnosed with OSA were offered positive airway pressure (PAP) therapy. We evaluated the impact of PAP on sleep-related symptoms, glycemic control, and hospitalization rates.
We identified 738 of 818 (90.1%) patients with type 2 diabetes as high risk for OSA. Only 29.2% (n = 213) of high risk patients were willing to undergo diagnostic sleep testing. The prevalence of OSA was 90.6% in this group, but only 66.0% of those with OSA initiated PAP. Patients with higher burden of sleep symptoms were more likely to pursue testing and initiate therapy. PAP use was associated with reduced sleep-related symptoms (mean Epworth sleepiness scale score declined from 8.8 to 7.3, p < .001), but did not impact hemoglobin A1c levels at one year (7.7-7.9%, p = .12). Changes in glycemic control and hospitalization rates did not differ from comparator groups.
Despite a high prevalence of OSA, willingness to pursue diagnostic testing and treatment was low in an unselected type 2 diabetes population. Furthermore, glycemic control did not improve. Future screening programs should focus on patients with substantial sleep related symptoms as this group is most likely to derive benefit from treatment.
按照当前指南的建议,我们测试了对2型糖尿病患者进行阻塞性睡眠呼吸暂停(OSA)筛查的可接受性及影响。
在一个大型城市初级保健机构中,我们为2型糖尿病患者开展了一项基于电话的OSA筛查项目,使用经过验证的工具(STOP-BANG)。被确定为高危的患者被转介进行诊断性睡眠测试,那些被诊断为OSA的患者接受气道正压通气(PAP)治疗。我们评估了PAP对睡眠相关症状、血糖控制和住院率的影响。
我们在818例2型糖尿病患者中确定了738例(90.1%)为OSA高危患者。只有29.2%(n = 213)的高危患者愿意接受诊断性睡眠测试。该组中OSA的患病率为90.6%,但只有66.0%的OSA患者开始使用PAP。睡眠症状负担较重的患者更有可能进行测试并开始治疗。使用PAP与睡眠相关症状减轻有关(平均爱泼华嗜睡量表评分从8.8降至7.3,p < 0.001),但对一年时的糖化血红蛋白水平没有影响(7.7 - 7.9%,p = 0.12)。血糖控制和住院率的变化与对照组无差异。
尽管OSA患病率很高,但在未经过挑选的2型糖尿病人群中,进行诊断性检测和治疗的意愿较低。此外,血糖控制并未改善。未来的筛查项目应关注有明显睡眠相关症状的患者,因为这组患者最有可能从治疗中获益。