The Randall Division, King's College London, London, UK; Ageing Research Laboratories, Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, UK; Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK.
Cardiovascular Research Centre, Institute for Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.
Exp Gerontol. 2018 Aug;109:5-15. doi: 10.1016/j.exger.2017.10.015. Epub 2017 Oct 18.
Cardiovascular disease (CVD) is the leading cause of death globally. One of the main risk factors for CVD is age, however the biological processes that occur in the heart during ageing are poorly understood. It is therefore important to understand the fundamental mechanisms driving heart ageing to enable the development of preventions and treatments targeting these processes. Cellular senescence is often described as the irreversible cell-cycle arrest which occurs in somatic cells. Emerging evidence suggests that cellular senescence plays a key role in heart ageing, however the cell-types involved and the underlying mechanisms are not yet elucidated. In this review we discuss the current understanding of how mechanisms known to contribute to senescence impact on heart ageing and CVD. Finally, we evaluate recent data suggesting that targeting senescent cells may be a viable therapy to counteract the ageing of the heart.
心血管疾病（CVD）是全球范围内的主要死亡原因之一。CVD 的一个主要危险因素是年龄，然而，人们对心脏在衰老过程中发生的生物学过程知之甚少。因此，了解驱动心脏衰老的基本机制对于开发针对这些过程的预防和治疗方法非常重要。细胞衰老通常被描述为体细胞中发生的不可逆细胞周期停滞。新出现的证据表明，细胞衰老在心脏衰老中起着关键作用，然而，涉及的细胞类型和潜在机制尚不清楚。在这篇综述中，我们讨论了目前对已知有助于衰老的机制如何影响心脏衰老和 CVD 的理解。最后，我们评估了最近的数据，表明靶向衰老细胞可能是一种可行的治疗方法，以对抗心脏衰老。
