University of California Irvine School of Medicine, Irvine, California.
Keck School of Medicine of the University of Southern California, Los Angeles, California.
J Am Acad Dermatol. 2018 Feb;78(2):395-402. doi: 10.1016/j.jaad.2017.08.042. Epub 2017 Oct 19.
The relationship between hidradenitis suppurativa and diabetes mellitus is not well understood.
To compare the prevalence of diabetes mellitus between patients with and without hidradenitis suppurativa.
We conducted a systematic review and meta-analysis, which included primary observational studies that reported the prevalence of diabetes mellitus among patients with hidradenitis suppurativa in the PubMed, Embase, Cochrane Library, LILACS, and Scielo databases from 1947 to June 13, 2017. A random effects model for pooled odds ratio was used for data analysis. Publication bias was assessed by funnel plot and the Egger test.
The systematic review included 107,050 patients from 14 studies; the meta-analysis included 104,373 patients from 7 studies. On the basis of meta-analysis, the prevalence of diabetes mellitus was 10.6% in patients with hidradenitis suppurativa and 3.8% in patients without hidradenitis suppurativa. Compared with the general population, patients with hidradenitis suppurativa were nearly 3 times more likely to have diabetes mellitus (pooled odds ratio, 2.78; 95% confidence interval, 1.79-4.31).
We were restricted by the quantity and quality of available data.
Hidradenitis suppurativa is significantly associated with an increased prevalence of diabetes mellitus.
化脓性汗腺炎与糖尿病之间的关系尚未完全明确。
比较化脓性汗腺炎患者与非化脓性汗腺炎患者的糖尿病患病率。
我们进行了一项系统评价和荟萃分析，纳入了从 1947 年至 2017 年 6 月 13 日期间在 PubMed、Embase、Cochrane 图书馆、LILACS 和 Scielo 数据库中发表的报告化脓性汗腺炎患者糖尿病患病率的原始观察性研究。采用随机效应模型对汇总比值比进行数据分析。采用漏斗图和 Egger 检验评估发表偏倚。
系统评价纳入了 14 项研究的 107050 例患者；荟萃分析纳入了 7 项研究的 104373 例患者。基于荟萃分析，化脓性汗腺炎患者的糖尿病患病率为 10.6%，而非化脓性汗腺炎患者的糖尿病患病率为 3.8%。与普通人群相比，化脓性汗腺炎患者发生糖尿病的可能性接近 3 倍（汇总比值比，2.78；95%置信区间，1.79-4.31）。
我们受到可用数据的数量和质量的限制。
化脓性汗腺炎与糖尿病患病率升高显著相关。
