Department of Cardiology, Vall d'Hebron Hospital, CIBERCV, Autonomous University of Barcelona, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.
Department of Cardiology, Vall d'Hebron Hospital, CIBERCV, Autonomous University of Barcelona, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP), Spain.
Int J Cardiol. 2018 Jan 1;250:35-42. doi: 10.1016/j.ijcard.2017.10.004. Epub 2017 Oct 5.
The relation between STEMI and air pollution (AP) is scant. We aimed to investigate the short term association between AP and the incidence of STEMI, and STEMI-related ventricular arrhythmias (VA) and mortality.
The study was carried out in the area of Barcelona from January 2010 to December 2011. Daily STEMI rates and incidence of STEMI-related VA and mortality were obtained prospectively. The corresponding daily levels of the main pollutants were recorded as well as the atmospheric variables. Three cohorts were defined in order to minimize exposure bias. The magnitude of association was estimated using a time-series design and was adjusted according to atmospheric variables.
The daily rate of hospital admissions for STEMI was associated with increases in PM 2.5, PM 10, lead and NO2 concentrations. VA incidence and mortality were associated with increases in PM 2.5 and PM 10 concentrations. In the most specific cohort, BCN (Barcelona) Attended & Resident, STEMI incidence was associated with increases in PM 2.5 (1.009% per 10μg/m) and PM 10 concentrations (1.005% per 10μg/m). VA was associated with increases in PM 2.5 (1.021%) and PM 10 (1.015%) and mortality was associated with increases in PM 2.5 (1.083%) and PM 10 (1.045%).
Short-term exposure to high levels of PM 2.5 and PM 10 is associated with increased daily STEMI admissions and STEMI-related VA and mortality. Exposure to high levels of lead and NO2 is associated with increased daily STEMI admissions, and NO2 with higher mortality in STEMI patients.
STMI 与空气污染（AP）之间的关系尚不清楚。我们旨在研究 AP 与 STEMI 发病率、STEMI 相关室性心律失常（VA）和死亡率之间的短期关联。
本研究于 2010 年 1 月至 2011 年 12 月在巴塞罗那地区进行。前瞻性获得每日 STEMI 发生率和 STEMI 相关 VA 及死亡率。记录主要污染物的相应日水平以及大气变量。为了最小化暴露偏差，定义了三个队列。使用时间序列设计估计关联的幅度，并根据大气变量进行调整。
每日 STEMI 住院率与 PM 2.5、PM 10、铅和 NO2 浓度升高相关。VA 发生率和死亡率与 PM 2.5 和 PM 10 浓度升高相关。在最具体的队列 BCN（巴塞罗那）Attended & Resident 中，STEMI 发病率与 PM 2.5（每 10μg/m 增加 1.009%）和 PM 10 浓度（每 10μg/m 增加 1.005%）升高相关。VA 与 PM 2.5（1.021%）和 PM 10（1.015%）升高相关，死亡率与 PM 2.5（1.083%）和 PM 10（1.045%）升高相关。
短期暴露于高水平的 PM 2.5 和 PM 10 与每日 STEMI 入院、STEMI 相关 VA 和死亡率增加相关。高水平的铅和 NO2 暴露与每日 STEMI 入院增加相关，而 NO2 与 STEMI 患者死亡率增加相关。
