Health Research Institute, Lithuanian University of Health Sciences, Tilzes St. 18, 47181 Kaunas, Lithuania.
Department of Environmental and Occupational Medicine, Lithuanian University of Health Sciences, Tilzes St. 18, 47181 Kaunas, Lithuania.
Int J Environ Res Public Health. 2023 Mar 3;20(5):4549. doi: 10.3390/ijerph20054549.
Air pollution has a significant effect on human health and there is a broad body of evidence showing that exposure to air pollution is associated with an increased risk of adverse health effects. The main objective of this study was to assess the association of traffic-related air pollutants with fatal AMI during the ten-year period.
The study was conducted in Kaunas city, where the WHO MONICA register included a total of 2273 adult cases of fatal AMI cases during the 10-year study period. We focused on the period between 2006 and 2015. The associations between exposure to traffic-related air pollution and the risk of fatal AMI were evaluated by using a multivariate Poisson regression model, RR presented per an increase in IQR.
It was found that the risk of fatal AMI was significantly higher in all subjects (RR 1.06; 95% CI 1.00-1.12) and women (RR 1.12; 95% CI 1.02-1.22) when the concentration of PM in the ambient air was increased 5-11 days before the onset of AMI, adjusting for NO concentration. The effect was stronger during spring in all subjects (RR 1.12; 95% CI 1.03-1.22), in men (RR 1.13; 95% CI 1.01-1.26), in younger-aged (RR 1.15; 95% CI 1.03-1.28), and in winter in women (RR 1.24; 95% CI 1.03-1.50).
Our findings show that ambient air pollution increases the risk of fatal AMI, and this pertains to PM specifically.
空气污染对人类健康有重大影响，有大量证据表明，暴露于空气污染与不良健康影响的风险增加有关。本研究的主要目的是评估在十年期间交通相关空气污染物与致命性 AMI 之间的关联。
该研究在考纳斯市进行，世界卫生组织 MONICA 登记册在十年研究期间共包括 2273 例致命性 AMI 成年病例。我们专注于 2006 年至 2015 年期间。使用多变量泊松回归模型评估接触交通相关空气污染物与致命性 AMI 风险之间的关联，RR 表示每增加一个 IQR 的风险比。
研究发现，在所有受试者（RR 1.06；95%CI 1.00-1.12）和女性（RR 1.12；95%CI 1.02-1.22）中，当环境空气中 PM 浓度在致命性 AMI 发作前 5-11 天增加时，致命性 AMI 的风险显著更高，调整了 NO 浓度。在所有受试者（RR 1.12；95%CI 1.03-1.22）、男性（RR 1.13；95%CI 1.01-1.26）、年轻年龄组（RR 1.15；95%CI 1.03-1.28）和女性冬季（RR 1.24；95%CI 1.03-1.50），这种影响更强。
我们的研究结果表明，环境空气污染增加了致命性 AMI 的风险，这与 PM 特别相关。
