Shaw Dana K, McClure Erin E, Wang Xiaowei, Pedra Joao H F
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Vet Sci. 2016 Sep 28;3(4):27. doi: 10.3390/vetsci3040027.
In the face of an assault, host cells mount an immediate response orchestrated by innate immunity. Two of the best described innate immune signaling networks are the Toll- and the Nod-like receptor pathways. Extensive work has been done characterizing both signaling cascades with several recent advances on the forefront of inflammasome biology. In this review, we will discuss how more commonly-studied pathogens differ from tick-transmitted microbes in the context of Nod-like receptor signaling and inflammasome formation. Because pathogens transmitted by ticks have unique characteristics, we offer the opinion that these microbes can be used to uncover novel principles of Nod-like receptor biology.
面对攻击时，宿主细胞会启动由先天免疫精心编排的即时反应。两个描述得最为详尽的先天免疫信号网络是Toll样受体途径和Nod样受体途径。在炎症小体生物学前沿领域有多项最新进展，针对这两种信号级联反应已经开展了大量研究。在本综述中，我们将讨论在Nod样受体信号传导和炎症小体形成的背景下，研究更为普遍的病原体与蜱传微生物有何不同。由于蜱传播的病原体具有独特特征，我们认为这些微生物可用于揭示Nod样受体生物学的新原理。
