Plotkin Lilian I, Pacheco-Costa Rafael, Davis Hannah M
Department of Anatomy & Cell Biology, Indianapolis, IN, USA.
Roudebush Veterans Administration Medical Center, Indianapolis, IN, USA.
Curr Mol Biol Rep. 2017 Jun;3(2):63-70. doi: 10.1007/s40610-017-0058-6. Epub 2017 Apr 25.
To describe the current knowledge on the cross-talk between connexins and microRNAs (miRs) in bone cells.
Connexins play a crucial role on bone development and maintenance, and disruptions in their abundance or localization can affect how bone perceives and responds to mechanical, hormonal, and pharmacological stimuli. Connexin expression can be modified by miRs, which modulate connexin mRNA and protein levels. Recently, different manners by which miRs and connexins can interact in bone have been identified, including mechanisms that mediate miR exchange between cells in direct contact through gap junctions, or between distant cells via extracellular vesicles (EVs).
We bring to light the relationship between miRs and connexins in bone tissue, with special focus on regulatory effects of miRs and connexins on gene expression, as well as the mechanisms that mediate miR exchange between cells in direct contact through gap junctions, or between distant cells via EVs.
描述目前关于骨细胞中连接蛋白与微小RNA（miR）之间相互作用的知识。
连接蛋白在骨骼发育和维持中起关键作用，其丰度或定位的破坏会影响骨骼对机械、激素和药理刺激的感知和反应方式。miR可修饰连接蛋白的表达，调节连接蛋白的mRNA和蛋白质水平。最近，已确定miR与连接蛋白在骨骼中相互作用的不同方式，包括通过间隙连接介导直接接触的细胞间miR交换，或通过细胞外囊泡（EV）在远距离细胞间进行miR交换的机制。
我们揭示了骨组织中miR与连接蛋白之间的关系，特别关注miR和连接蛋白对基因表达的调节作用，以及通过间隙连接介导直接接触的细胞间或通过EV在远距离细胞间进行miR交换的机制。
