Böttiger B, Palme I B, da Costa J L, Dias L F, Biberfeld G
Department of Immunology, National Bacteriological Laboratory, Stockholm, Sweden.
J Acquir Immune Defic Syndr (1988). 1988;1(1):8-12.
A seroepidemiological study of human immune deficiency virus type 1 (HIV-1) and HIV-2/human T-lymphotropic virus type IV (HIV-2/HTLV-IV) infections was performed in Angola in October 1986. Until then five cases of acquired immune deficiency syndrome (AIDS) had been registered in Angola. During this study, another three cases with clinical AIDS were found and confirmed by HIV-1 serology. A total of 1,215 sera from groups of healthy persons and patients were tested for HIV-1 and HIV-2/HTLV-IV antibodies by enzyme-linked immunosorbent assays (ELISA). Sera positive by ELISA were also tested by Western blot (WB) analysis. In Luanda, the capital, HIV-1 antibodies were demonstrated in 0.4% (2/452) of male blood donors, in 0.3% (1/357) of pregnant women, in 1% (1/100) of tuberculosis patients, in 4% (4/94) of patients at medical wards, and in none of 22 women hospitalized with pelvic infections. In the Cabinda province, 11% (4/38) of postnatal women at a maternity ward were found to be HIV-1 seropositive, but only 2% (1/55) of other hospitalized patients and none of 32 male blood donors or 59 healthy persons in a village on the border to Zaire. Specific antibodies to HIV-2/HTLV-IV were not found in any of the sera. However, 16 out of 17 HIV-1 positive sera cross-reacted with HIV-2/HTLV-IV core proteins by WB. In October 1987, 280 of the blood donors from Luanda were retested for HIV-1 antibodies and one of them was found to have seroconverted during the previous year.(ABSTRACT TRUNCATED AT 250 WORDS)
1986年10月在安哥拉进行了一项关于1型人类免疫缺陷病毒（HIV-1）和HIV-2/人类嗜T淋巴细胞病毒IV型（HIV-2/HTLV-IV）感染的血清流行病学研究。在此之前，安哥拉已登记了5例获得性免疫缺陷综合征（AIDS）病例。在这项研究期间，又发现了另外3例临床AIDS病例，并通过HIV-1血清学得到证实。通过酶联免疫吸附测定（ELISA）对来自健康人群和患者组的1215份血清进行了HIV-1和HIV-2/HTLV-IV抗体检测。ELISA检测呈阳性的血清也通过免疫印迹（WB）分析进行了检测。在首都罗安达，0.4%（2/452）的男性献血者、0.3%（1/357）的孕妇、1%（1/100）的结核病患者、4%（4/94）的内科病房患者以及22例因盆腔感染住院的女性中均检测到HIV-1抗体。在卡宾达省，一家产科病房11%（4/38）的产后妇女被发现HIV-1血清学呈阳性，但在其他住院患者中只有2%（1/55）呈阳性，在与扎伊尔接壤边境的一个村庄的32名男性献血者和59名健康人中均未检测到。在任何一份血清中均未发现针对HIV-2/HTLV-IV的特异性抗体。然而，17份HIV-1阳性血清中有16份通过WB与HIV-2/HTLV-IV核心蛋白发生交叉反应。1987年10月，对来自罗安达的280名献血者重新检测了HIV-1抗体，其中1人在前一年血清发生了转化。（摘要截选至250词）
