Zhang Fuyou, Li Jianfa, Xiao Huizhong, Zou Yifan, Liu Yuchen, Huang Weiren
Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, 518039, Guangdong Province, China.
Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, 518036, China.
Cell Prolif. 2018 Feb;51(1). doi: 10.1111/cpr.12397. Epub 2017 Oct 22.
Long non-coding RNAs (lncRNAs), a group of non-protein-coding RNAs with more than 200 nucleotides in length, are involved in multiple biological processes, such as the proliferation, apoptosis, migration and invasion. Moreover, numerous studies have shown that lncRNAs play important roles as oncogenes or tumour suppressor genes in human cancers. In this paper, we concentrate on actin filament-associated protein 1-antisense RNA 1 (AFAP1-AS1), a well-known long non-coding RNA that is overexpressed in various tumour tissues and cell lines, including oesophageal cancer, pancreatic ductal adenocarcinoma, nasopharyngeal carcinoma, lung cancer, hepatocellular carcinoma, ovarian cancer, colorectal cancer, biliary tract cancer and gastric cancer. Moreover, high expression of AFAP1-AS1 was associated with the clinicopathological features and cancer progression. In this review, we sum up the current studies on the characteristics of AFAP1-AS1 in the biological function and mechanism of human cancers.
长链非编码RNA（lncRNAs）是一类长度超过200个核苷酸的非蛋白质编码RNA，参与多种生物学过程，如增殖、凋亡、迁移和侵袭。此外，大量研究表明，lncRNAs在人类癌症中作为癌基因或肿瘤抑制基因发挥重要作用。在本文中，我们聚焦于肌动蛋白丝相关蛋白1反义RNA 1（AFAP1-AS1），这是一种著名的长链非编码RNA，在包括食管癌、胰腺导管腺癌、鼻咽癌、肺癌、肝细胞癌、卵巢癌、结直肠癌、胆管癌和胃癌在内的各种肿瘤组织和细胞系中均有过表达。此外，AFAP1-AS1的高表达与临床病理特征及癌症进展相关。在本综述中，我们总结了目前关于AFAP1-AS1在人类癌症生物学功能和机制方面特征的研究。
