Xiong Guangbing, Pan Shutao, Jin Jikuan, Wang Xiaoxiang, He Ruizhi, Peng Feng, Li Xu, Wang Min, Zheng Jianwei, Zhu Feng, Qin Renyi
Department of Biliary-Pancreatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Oncol. 2021 Oct 25;11:765216. doi: 10.3389/fonc.2021.765216. eCollection 2021.
Pancreatic cancer (PC) is a highly malignant disease characterized by insidious onset, rapid progress, and poor therapeutic effects. The molecular mechanisms associated with PC initiation and progression are largely insufficient, hampering the exploitation of novel diagnostic biomarkers and development of efficient therapeutic strategies. Emerging evidence recently reveals that noncoding RNAs (ncRNAs), including long ncRNAs (lncRNAs) and microRNAs (miRNAs), extensively participate in PC pathogenesis. Specifically, lncRNAs can function as competing endogenous RNAs (ceRNAs), competitively sequestering miRNAs, therefore modulating the expression levels of their downstream target genes. Such complex lncRNA/miRNA/mRNA networks, namely, ceRNA networks, play crucial roles in the biological processes of PC by regulating cell growth and survival, epithelial-mesenchymal transition and metastasis, cancer stem cell maintenance, metabolism, autophagy, chemoresistance, and angiogenesis. In this review, the emerging knowledge on the lncRNA-associated ceRNA networks involved in PC initiation and progression will be summarized, and the potentials of the competitive crosstalk as diagnostic, prognostic, and therapeutic targets will be comprehensively discussed.
胰腺癌（PC）是一种高度恶性的疾病，其特点是起病隐匿、进展迅速且治疗效果不佳。与胰腺癌发生和进展相关的分子机制在很大程度上尚不明确，这阻碍了新型诊断生物标志物的开发以及有效治疗策略的制定。最近新出现的证据表明，包括长链非编码RNA（lncRNA）和微小RNA（miRNA）在内的非编码RNA广泛参与胰腺癌的发病机制。具体而言，lncRNA可作为竞争性内源性RNA（ceRNA），竞争性地结合miRNA，从而调节其下游靶基因的表达水平。这种复杂的lncRNA/miRNA/mRNA网络，即ceRNA网络，通过调节细胞生长和存活、上皮-间质转化和转移、癌症干细胞维持、代谢、自噬、化疗耐药性和血管生成，在胰腺癌的生物学过程中发挥关键作用。在本综述中，将总结有关lncRNA相关ceRNA网络参与胰腺癌发生和进展的新认识，并全面讨论竞争性相互作用作为诊断、预后和治疗靶点的潜力。
