Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA.
Chem Soc Rev. 2023 Jun 6;52(11):3927-3945. doi: 10.1039/d3cs00167a.
Transition metal dysregulation is associated with a host of pathologies, many of which are therapeutically targeted using chelators and ionophores. Chelators and ionophores are used as therapeutic metal-binding compounds which impart biological effects by sequestering or trafficking endogenous metal ions in an effort to restore homeostasis. Many current therapies take inspiration or derive directly from small molecules and peptides found in plants. This review focuses on plant-derived small molecule and peptide chelators and ionophores that can affect metabolic disease states. Understanding the coordination chemistry, bioavailability, and bioactivity of such molecules provides the tools to further research applications of plant-based chelators and ionophores.
过渡金属失调与许多病理学有关，其中许多病理学可以通过螯合剂和离子载体来治疗。螯合剂和离子载体被用作治疗性金属结合化合物，通过螯合或运输内源性金属离子来发挥生物效应，从而恢复体内平衡。许多当前的治疗方法受到植物中小分子和肽的启发或直接来源于它们。本综述重点介绍了可影响代谢疾病状态的植物来源的小分子和肽螯合剂和离子载体。了解这些分子的配位化学、生物利用度和生物活性为进一步研究基于植物的螯合剂和离子载体的应用提供了工具。
