Clinical Eye Research Division, Department of Ophthalmology, Zealand University Hospital, Roskilde, Denmark.
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Retina. 2018 Dec;38(12):2363-2371. doi: 10.1097/IAE.0000000000001872.
Polypoidal choroidal vasculopathy (PCV) is a disease with significant inter-ethnical differences. In this study, we systematically review the literature on the prevalence of PCV in whites referred with a diagnosis of exudative age-related macular degeneration (AMD).
We searched PubMed, Embase, the Cochrane Library, and the Web of Science on 24 March, 2017 for studies evaluating the prevalence of PCV in white patients with exudative AMD. Data extraction and risk of bias assessments were performed in duplicate. Studies were included for a qualitative review and a meta-analysis, including subgroup analysis for differences in age and sex.
We included data from 11 studies (>2,200 participants). For diagnosis, indocyanine green angiography was used together with a set of supporting criteria on fundus examination and optical coherence tomography. Extramacular location was more prevalent in eyes with PCV. Drusen was present in the fellow eye in 17% to 27%. Pooled prevalence of PCV in white patients with exudative AMD was 8.7% (confidence interval 95%: 7.2%-10.3%). Patients with PCV were 3.7 years (confidence interval 95%: 2.1 years-5.3 years) younger than those with other exudative AMD. Sex did not differ significantly.
Polypoidal choroidal vasculopathy is not a rare subtype of exudative AMD in whites-it is present in approximately one in 11 patients.
息肉样脉络膜血管病变（PCV）是一种具有显著种族间差异的疾病。本研究系统地回顾了白人中以渗出性年龄相关性黄斑变性（AMD）为诊断的 PCV 患病率的文献。
我们于 2017 年 3 月 24 日在 PubMed、Embase、Cochrane 图书馆和 Web of Science 上检索了评估白人渗出性 AMD 患者中 PCV 患病率的研究。数据提取和偏倚风险评估由两人独立进行。对研究进行定性综述和荟萃分析，包括年龄和性别差异的亚组分析。
我们纳入了 11 项研究（超过 2200 名参与者）的数据。对于诊断，使用吲哚菁绿血管造影，并结合眼底检查和光学相干断层扫描的一系列支持标准。PCV 眼的黄斑外位置更为常见。在伴有 PCV 的眼中，有 17%至 27%的患者存在玻璃膜疣。白人渗出性 AMD 患者中 PCV 的总患病率为 8.7%（置信区间 95%：7.2%-10.3%）。患有 PCV 的患者比患有其他渗出性 AMD 的患者年轻 3.7 岁（置信区间 95%：2.1 岁-5.3 岁）。性别差异无统计学意义。
PCV 并非白人渗出性 AMD 的罕见亚型-约每 11 名患者中就有 1 名患有 PCV。
