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成年雌性猪蛔虫组织中血清素（5-羟色胺）的周转率

Serotonin (5-hydroxytryptamine) turnover in adult female Ascaris suum tissue.

作者信息

Martin R E, Chaudhuri J, Donahue M J

机构信息

Department of Biological Sciences, University of North Texas, Denton 76203.

出版信息

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1988;91(2):307-10. doi: 10.1016/0742-8413(88)90034-5.

DOI:10.1016/0742-8413(88)90034-5
PMID:2905947
Abstract
  1. The 5-hydroxytryptamine (5-HT, serotonin) turnover was examined in the tissues of adult female Ascaris suum. The 5-HT turnover was highest in the intestine at 34.7 ng 5-HT produced/mg protein/hr and 13.8 ng 5-HT produced/mg protein/hr in muscle tissue. 2. The levels of 5-HT metabolites namely tryptophan, 5-hydroxytryptophan, 5-hydroxytryptamine, 5-hydroxyindole acetic acid and 5-hydroxytryptophol were measured in muscle and intestinal tissue of adult A. suum. 3. Parachlorophenylalanine inhibited 5-HT production in muscle and intestinal tissue providing in situ evidence for the presence of tryptophan hydroxylase in this tissue. 4. Pargyline increased 5-HT production in muscle and intestinal tissue providing in situ evidence for the presence of monoamine oxidase in this tissue.
摘要
  1. 检测了成年雌性猪蛔虫组织中的5-羟色胺（5-HT，血清素）周转率。5-HT周转率在肠道中最高，为每毫克蛋白质每小时产生34.7纳克5-HT，在肌肉组织中为每毫克蛋白质每小时产生13.8纳克5-HT。2. 测定了成年猪蛔虫肌肉和肠道组织中5-HT代谢产物的水平，即色氨酸、5-羟色氨酸、5-羟色胺、5-羟吲哚乙酸和5-羟色醇。3. 对氯苯丙氨酸抑制了肌肉和肠道组织中5-HT的产生，为该组织中色氨酸羟化酶的存在提供了原位证据。4. 优降宁增加了肌肉和肠道组织中5-HT的产生，为该组织中存在单胺氧化酶提供了原位证据。

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