Sclocco Roberta, Garcia Ronald G, Gabriel Aileen, Kettner Norman W, Napadow Vitaly, Barbieri Riccardo
Annu Int Conf IEEE Eng Med Biol Soc. 2017 Jul;2017:3130-3133. doi: 10.1109/EMBC.2017.8037520.
Transcutaneous stimulation of the auricular branch of the vagus nerve (ABVN) has been proposed as a non-invasive alternative to vagus nerve stimulation (VNS). However, its cardiovagal effects are inconsistent across studies, likely due to inhomogeneity in the stimulation parameters. Here, we evaluate respiratory-gated ABVN stimulation (Respiratory-gated Auricular Vagal Afferent Nerve Stimulation, RAVANS), where the stimuli are delivered in 1 s bursts during the exhalation phase of respiration, thus mimicking the breathing-induced modulation of cardiac vagal activity. In this study, we present preliminary results from an ongoing single-arm, open label trial investigating the effects of different intensities of RAVANS in hypertensive subjects. We found that a mid-intensity RAVANS stimulation (rated as a 5 on a 0-10 scale) increases the cardiovagal tone and reduces the sympathetic tone during a paced breathing task. The present results could contribute to optimize RAVANS as a non-invasive, low-cost therapeutic intervention for hypertension.
经皮刺激迷走神经耳支(ABVN)已被提议作为迷走神经刺激(VNS)的一种非侵入性替代方法。然而,其对心脏迷走神经的影响在不同研究中并不一致,这可能是由于刺激参数的不均匀性所致。在此,我们评估呼吸门控ABVN刺激(呼吸门控耳迷走传入神经刺激,RAVANS),即刺激在呼吸呼气阶段以1秒的脉冲形式发放,从而模拟呼吸诱导的心脏迷走神经活动调制。在本研究中,我们展示了一项正在进行的单臂、开放标签试验的初步结果,该试验旨在研究不同强度的RAVANS对高血压患者的影响。我们发现,中等强度的RAVANS刺激(在0至10的量表上评为5)在定频呼吸任务期间会增加心脏迷走神经张力并降低交感神经张力。目前的结果可能有助于优化RAVANS,使其成为一种用于高血压的非侵入性、低成本治疗干预措施。
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