心血管生理学和病理生理学中的迷走神经：从进化的角度到临床医学。
The vagus nerve in cardiovascular physiology and pathophysiology: From evolutionary insights to clinical medicine.
机构信息
Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
University of California, Los Angeles (UCLA) Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; UCLA Molecular, Cellular, and Integrative Physiology Program, Los Angeles, CA, USA.
出版信息
Semin Cell Dev Biol. 2024 Mar 15;156:190-200. doi: 10.1016/j.semcdb.2023.01.001. Epub 2023 Jan 12.
Abstract
The parasympathetic nervous system via the vagus nerve exerts profound influence over the heart. Together with the sympathetic nervous system, the parasympathetic nervous system is responsible for fine-tuned regulation of all aspects of cardiovascular function, including heart rate, rhythm, contractility, and blood pressure. In this review, we highlight vagal efferent and afferent innervation of the heart, with a focus on insights from comparative biology and advances in understanding the molecular and genetic diversity of vagal neurons, as well as interoception, parasympathetic dysfunction in heart disease, and the therapeutic potential of targeting the parasympathetic nervous system in cardiovascular disease.
摘要
副交感神经系统通过迷走神经对心脏产生深远影响。副交感神经系统与交感神经系统一起，负责精细调节心血管功能的各个方面，包括心率、节律、收缩性和血压。在这篇综述中，我们强调了心脏的迷走传出和传入神经支配，重点介绍了比较生物学的见解和对迷走神经元分子和遗传多样性以及内脏感知、心脏病中心副交感神经功能障碍的理解的进展，以及针对心血管疾病中副交感神经系统的治疗潜力。
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