Obeid Mohammad A, Al Qaraghuli Mohammed M, Alsaadi Manal, Alzahrani Abdullah R, Niwasabutra Kanidta, Ferro Valerie A
Strathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow, G4 0RE, UK.
Faculty of Pharmacy, Yarmouk University, Irbid, Jordan.
Ther Deliv. 2017 Nov;8(11):947-956. doi: 10.4155/tde-2017-0060.
Due to the increasing problem of drug resistance, new and improved medicines are required. Natural products and biotherapeutics offer a vast resource for new drugs; however, challenges, including the cost and time taken for traditional drug discovery processes and the subsequent lack of investment from the pharmaceutical industry, are associated with these areas. New techniques are producing compounds with appropriate activity at a faster rate. While the formulation of these combined with drug-delivery systems offers a promising approach for expanding the drug developments available to modern medicine. Here, various classes of drug-delivery systems are described and the advantages they bring to small molecule and biotherapeutic targeting are highlighted. This is an attractive approach to the pharmaceutical industry and the rising trend in research in this area is examined in brief. [Formula: see text].
由于耐药性问题日益严重,需要新的和改进的药物。天然产物和生物疗法为新药提供了丰富的资源;然而,这些领域存在一些挑战,包括传统药物研发过程的成本和时间,以及随后制药行业缺乏投资。新技术正在以更快的速度生产具有适当活性的化合物。虽然将这些化合物与药物递送系统相结合的配方为扩展现代医学可用的药物开发提供了一种有前景的方法。在此,描述了各类药物递送系统,并强调了它们给小分子和生物治疗靶向带来的优势。这对制药行业来说是一种有吸引力的方法,并简要探讨了该领域研究的上升趋势。[公式:见正文]