Pedrotti Emilio, Demasi Christian Luigi, Bruni Enrico, Bosello Francesca, Di Sarro Paolo Plinio, Passilongo Mattia, Fasolo Adriano, Gennaro Nicola, De Gregorio Alessandra, Ferrari Marcello, Marchini Giorgio
Department of Neurosciences, Biomedicine and Movement Sciences, Eye Clinic, University of Verona, Verona, Italy.
The Veneto Eye Bank Foundation, Venezia Zelarino, Italy.
BMJ Open. 2017 Oct 22;7(10):e016142. doi: 10.1136/bmjopen-2017-016142.
To assess the occurrence of glaucoma, eyelid, corneal and macular disorders in a cohort of patients with obstructive sleep apnoea (OSA) diagnosed by overnight polysomnography and to investigate into the risk factors for the above eye diseases (EDs).
Cross-sectional cohort study between 2014 and 2015.
Unit of Respiratory Medicine and Eye Clinic of the University of Verona.
431 consecutive patients were considered eligible. Of these, 87 declined to participate, 35 were untraceable and 13 were deceased.
A complete ophthalmic evaluation of both eyes for each patient.
Best-corrected distance visual acuity, intraocular pressure, corneal, macular and optic nerve optical coherence tomography, ocular aberrometry, optic nerve laser polarimetry, visual field test, and eyelid examination.
296 patients aged 64.5±12.8 years, 23% female and 77% male, underwent ophthalmic examination. There was 56% (n=166) prevalence of eyelid disorders, 27% (n=80) of corneal disorders, 13% (n=39) of macular disorders and 11% (n=33) of glaucoma. Advancing age was not associated with the severity of OSA, while significant differences were found for gender, body mass index, Oxygen Desaturation Index, smoking habit, hypertension and diabetes. Severe OSA was significantly associated with glaucoma (OR, 95% CI 1.05 to 5.93, p=0.037).
EDs were more prevalent in our patinets with OSA than in the general population. Severe Apnoea/Hypopnoea Index level seemed to play a role as risk factor only for glaucoma.
评估经夜间多导睡眠图诊断的阻塞性睡眠呼吸暂停（OSA）患者队列中青光眼、眼睑、角膜和黄斑疾病的发生率，并调查上述眼部疾病（EDs）的危险因素。
2014年至2015年的横断面队列研究。
维罗纳大学呼吸内科和眼科诊所。
431例连续患者被认为符合条件。其中，87例拒绝参与，35例无法追踪，13例死亡。
对每位患者的双眼进行全面眼科评估。
最佳矫正远距离视力、眼压、角膜、黄斑和视神经光学相干断层扫描、眼像差测量、视神经激光偏振测量、视野检查和眼睑检查。
296例年龄为64.5±12.8岁的患者接受了眼科检查，其中女性占23%，男性占77%。眼睑疾病患病率为56%（n = 166），角膜疾病为27%（n = 80），黄斑疾病为13%（n = 39），青光眼为11%（n = 33）。年龄增长与OSA严重程度无关，而在性别、体重指数、氧饱和度指数、吸烟习惯、高血压和糖尿病方面存在显著差异。重度OSA与青光眼显著相关（OR，95%CI 1.05至5.93，p = 0.037）。
我们的OSA患者中EDs的患病率高于一般人群。严重呼吸暂停/低通气指数水平似乎仅作为青光眼的危险因素起作用。
