Balbay Ege G, Balbay Oner, Annakkaya Ali N, Suner Kezban O, Yuksel Harun, Tunç Murat, Arbak Peri
Department of Chest Diseases, Faculty of Medicine, Düzce University, 81620 Düzce, Turkey.
Department of Ophthalmology, Faculty of Medicine, Düzce University, 81620 Düzce, Turkey.
Hong Kong Med J. 2014 Oct;20(5):379-85. doi: 10.12809/hkmj134021. Epub 2014 Jun 6.
To investigate the prevalence of obstructive sleep apnoea syndrome in patients with primary open-angle glaucoma.
Case series.
School of Medicine, Düzce University, Turkey.
Twenty-one consecutive primary open-angle glaucoma patients (12 females and 9 males) who attended the out-patient clinic of the Department of Ophthalmology between July 2007 and February 2008 were included in this study. All patients underwent polysomnographic examination.
The prevalence of obstructive sleep apnoea syndrome was 33.3% in patients with primary open-angle glaucoma; the severity of the condition was mild in 14.3% and moderate in 19.0% of the subjects. The age (P=0.047) and neck circumference (P=0.024) in patients with obstructive sleep apnoea syndrome were significantly greater than those without the syndrome. Triceps skinfold thickness in glaucomatous obstructive sleep apnoea syndrome patients reached near significance versus those without the syndrome (P=0.078). Snoring was observed in all glaucoma cases with obstructive sleep apnoea syndrome. The intra-ocular pressure of patients with primary open-angle glaucoma with obstructive sleep apnoea syndrome was significantly lower than those without obstructive sleep apnoea syndrome (P=0.006 and P=0.035 for the right and left eyes, respectively). There was no significant difference in the cup/disc ratio and visual acuity, except visual field defect, between primary open-angle glaucoma patients with and without obstructive sleep apnoea syndrome.
Although it does not provide evidence for a cause-effect relationship, high prevalence of obstructive sleep apnoea syndrome in patients with primary open-angle glaucoma in this study suggests the need to explore the long-term results of coincidence, relationship, and cross-interaction of these two common disorders.
研究原发性开角型青光眼患者阻塞性睡眠呼吸暂停综合征的患病率。
病例系列研究。
土耳其杜兹切大学医学院。
纳入2007年7月至2008年2月期间在眼科门诊就诊的21例连续原发性开角型青光眼患者（12例女性和9例男性）。所有患者均接受多导睡眠图检查。
原发性开角型青光眼患者阻塞性睡眠呼吸暂停综合征的患病率为33.3%；病情严重程度为轻度的患者占14.3%，中度的占19.0%。阻塞性睡眠呼吸暂停综合征患者的年龄（P=0.047）和颈围（P=0.024）显著高于无该综合征的患者。青光眼合并阻塞性睡眠呼吸暂停综合征患者的肱三头肌皮褶厚度与无该综合征患者相比接近显著差异（P=0.078）。所有青光眼合并阻塞性睡眠呼吸暂停综合征的病例均有打鼾现象。原发性开角型青光眼合并阻塞性睡眠呼吸暂停综合征患者的眼压显著低于无阻塞性睡眠呼吸暂停综合征的患者（右眼和左眼分别为P=0.006和P=0.035）。原发性开角型青光眼合并和不合并阻塞性睡眠呼吸暂停综合征的患者之间，除视野缺损外，杯盘比和视力无显著差异。
尽管本研究未提供因果关系的证据，但原发性开角型青光眼患者中阻塞性睡眠呼吸暂停综合征的高患病率表明，有必要探索这两种常见疾病的巧合、关系和交叉相互作用的长期结果。
