Vecsei L, Widerlöv E
Department of Psychiatry and Neurochemistry, University of Lund, Sweden.
Acta Psychiatr Scand. 1988 Dec;78(6):657-67. doi: 10.1111/j.1600-0447.1988.tb06401.x.
Somatostatin was originally isolated as a 14-amino-acid peptide from the ovine hypothalamus. The peptide has a widespread regional distribution within the central and peripheral nervous systems, as well as in peripheral organs. Preservation of the chemical structure over a wide range of vertebral species indicates important functional roles of the peptide. Recent results about the role of somatostatin and related peptides in different psychiatric (depression, schizophrenia, Alzheimer's disease) and neurological (Huntington's disease, multiple sclerosis, Parkinson's disease) diseases, and the effects on the hypothalamic-pituitary-adrenal axis are summarized. Also, the influence of some psychotropic drugs (halo-peridol, carbamazepine) on somatostatin levels in cerebrospinal fluid is discussed.
生长抑素最初是从绵羊下丘脑中分离出的一种含14个氨基酸的肽。该肽在中枢和外周神经系统以及外周器官中广泛分布。在多种脊椎动物物种中化学结构的保留表明该肽具有重要的功能作用。本文总结了关于生长抑素及相关肽在不同精神疾病（抑郁症、精神分裂症、阿尔茨海默病）和神经疾病（亨廷顿病、多发性硬化症、帕金森病）中的作用以及对下丘脑-垂体-肾上腺轴的影响的最新研究结果。此外，还讨论了一些精神药物（氟哌啶醇、卡马西平）对脑脊液中生长抑素水平的影响。
