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神经和精神疾病中的脑脊液血管加压素

Cerebrospinal fluid vasopressin in neurological and psychiatric disorders.

作者信息

Sørensen P S, Gjerris A, Hammer M

出版信息

J Neurol Neurosurg Psychiatry. 1985 Jan;48(1):50-7. doi: 10.1136/jnnp.48.1.50.

Abstract

Vasopressin was determined in CSF and plasma of 243 patients with different neurological and psychiatric disorders, including control patients. CSF vasopressin was significantly higher in patients with high pressure hydrocephalus, intracranial tumour, benign intracranial hypertension, intracranial haemorrhage, ischaemic stroke, and craniocerebral trauma. In patients with primary degenerative dementia, CSF vasopressin was lower than in control patients. Among patients with psychiatric disorders, CSF vasopressin was increased in manic patients, while in patients with depression CSF concentration of this hormone did not differ from that found in controls. However, an increase in CSF vasopressin level was found in patients recovering from a depression. The clinical significance of changes in CSF vasopressin concentrations in groups of patients with neurological and psychiatric disorders is still unknown.

摘要

在243例患有不同神经和精神疾病的患者(包括对照患者)的脑脊液和血浆中测定了血管加压素。在高压脑积水、颅内肿瘤、良性颅内高压、颅内出血、缺血性中风和颅脑外伤患者中,脑脊液血管加压素显著升高。在原发性退行性痴呆患者中,脑脊液血管加压素低于对照患者。在精神疾病患者中,躁狂患者的脑脊液血管加压素升高,而抑郁症患者脑脊液中该激素的浓度与对照组无差异。然而,在从抑郁症中恢复的患者中发现脑脊液血管加压素水平升高。神经和精神疾病患者组中脑脊液血管加压素浓度变化的临床意义仍不清楚。

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J Clin Endocrinol Metab. 1980 Feb;50(2):364-7. doi: 10.1210/jcem-50-2-364.
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