Segovia Fermín, Górriz Juan M, Ramírez Javier, Martínez-Murcia Francisco J, Salas-Gonzalez Diego
Department of Signal Theory, Networking and Communications, University of Granada, Granada, Spain.
Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom.
Front Aging Neurosci. 2017 Oct 9;9:326. doi: 10.3389/fnagi.2017.00326. eCollection 2017.
F-DMFP-PET is an emerging neuroimaging modality used to diagnose Parkinson's disease (PD) that allows us to examine postsynaptic dopamine receptors. Like other neuroimaging modalities used for PD diagnosis, most of the total intensity of F-DMFP-PET images is concentrated in the striatum. However, other regions can also be useful for diagnostic purposes. An appropriate delimitation of the regions of interest contained in F-DMFP-PET data is crucial to improve the automatic diagnosis of PD. In this manuscript we propose a novel methodology to preprocess F-DMFP-PET data that improves the accuracy of computer aided diagnosis systems for PD. First, the data were segmented using an algorithm based on Hidden Markov Random Field. As a result, each neuroimage was divided into 4 maps according to the intensity and the neighborhood of the voxels. The maps were then individually normalized so that the shape of their histograms could be modeled by a Gaussian distribution with equal parameters for all the neuroimages. This approach was evaluated using a dataset with neuroimaging data from 87 parkinsonian patients. After these preprocessing steps, a Support Vector Machine classifier was used to separate idiopathic and non-idiopathic PD. Data preprocessed by the proposed method provided higher accuracy results than the ones preprocessed with previous approaches.
F-DMFP-PET是一种新兴的神经成像模态,用于诊断帕金森病(PD),它能让我们检查突触后多巴胺受体。与用于PD诊断的其他神经成像模态一样,F-DMFP-PET图像的总强度大部分集中在纹状体。然而,其他区域对诊断也可能有用。对F-DMFP-PET数据中感兴趣区域进行适当界定对于提高PD的自动诊断至关重要。在本手稿中,我们提出了一种新颖的方法来预处理F-DMFP-PET数据,以提高PD计算机辅助诊断系统的准确性。首先,使用基于隐马尔可夫随机场的算法对数据进行分割。结果,每个神经图像根据体素的强度和邻域被分为4个图谱。然后对这些图谱分别进行归一化处理,以便其直方图的形状可以用一个对所有神经图像具有相同参数的高斯分布来建模。使用一个包含87名帕金森病患者神经成像数据的数据集对该方法进行了评估。经过这些预处理步骤后,使用支持向量机分类器来区分特发性和非特发性PD。用所提出的方法预处理后的数据比用以前的方法预处理后的数据提供了更高的准确率结果。