在临床产生TEM-1和CMY-2的菌株中发现的新基因变体的遗传背景及表达
Genetic Background and Expression of the New Gene Variant Recovered in Clinical TEM-1- and CMY-2-Producing .
作者信息
Manageiro Vera, Félix David, Jones-Dias Daniela, Sampaio Daniel A, Vieira Luís, Sancho Luísa, Ferreira Eugénia, Caniça Manuela
机构信息
National Reference Laboratory of Antibiotic Resistances and Healthcare Associated Infections, Department of Infectious Diseases, National Institute of Health Doutor Ricardo Jorge, Lisbon, Portugal.
Centre for the Studies of Animal Science, Institute of Agrarian and Agri-Food Sciences and Technologies, University of Porto, Oporto, Portugal.
出版信息
Front Microbiol. 2017 Oct 9;8:1899. doi: 10.3389/fmicb.2017.01899. eCollection 2017.
A new QepA4 variant was detected in an O86:H28 ST156-, showing a multidrug-resistance phenotype. PAβN inhibition of harboring transconjugant resulted in increase of nalidixic acid accumulation. The and genes were clustered in a 26.0-kp contig matching an IncF-type plasmid, and containing a Tn21-type transposon with multiple mobile genetic elements. This QepA variant is worrisome because these determinants might facilitate the selection of higher-level resistance mutants, playing a role in the development of resistance, and/or confer higher-level resistance to fluoroquinolones in association with chromosomal mutations.
在一株O86:H28 ST156菌株中检测到一种新的QepA4变体，呈现出多重耐药表型。携带转接合子的PAβN抑制导致萘啶酸积累增加。qepA和qnr基因聚集在一个26.0-kp的重叠群中，与IncF型质粒匹配，并包含一个带有多个移动遗传元件的Tn21型转座子。这种QepA变体令人担忧，因为这些决定因素可能有助于选择更高水平的耐药突变体，在耐药性发展中起作用，和/或与染色体突变相关，赋予对氟喹诺酮类药物更高水平的耐药性。
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