De Saedeleer V, Wechsung E, Houvenaghel A
Laboratory of Veterinary Physiology, State University Centre of Antwerp, Belgium.
Prostaglandins Leukot Essent Fatty Acids. 1992 Jan;45(1):71-5. doi: 10.1016/0952-3278(92)90105-r.
In 5 conscious piglets with electrodes implanted on the antrum pylori, duodenum, jejunum and ileum, the effect of intravenous infusion of PGF2 alpha, 1 and 10 micrograms/kg/min during 2 h, on gastrointestinal electrical activity was studied. The influence of the PG, 10(-8) to 10(-4) M, on longitudinal tissue strips from the same segments was also examined. The in vitro results demonstrate that PGF2 alpha has only a weak contractile effect on duodenal and jejunal strips. This effect was enhanced in the presence of atropine and indomethacin. In the in vivo part of the study PGF2 alpha induced an inhibition of antral electrical activity as evidenced by a prolongation of the inhibitory phases and a reduction of the frequency of the fast oscillations. In the small intestine only ileal activity was changed significantly. PGF2 alpha provoked an increase in the phase II or irregular spiking activity and an increase in the interval of the migrating myoelectrical complexes in this segment.
在5只将电极植入幽门窦、十二指肠、空肠和回肠的清醒仔猪中，研究了在2小时内以1和10微克/千克/分钟的速度静脉输注前列腺素F2α对胃肠电活动的影响。还检查了10（-8）至10（-4）M的前列腺素对相同节段纵向组织条的影响。体外结果表明，前列腺素F2α对十二指肠和空肠条只有微弱的收缩作用。在阿托品和吲哚美辛存在的情况下，这种作用增强。在该研究的体内部分，前列腺素F2α导致胃窦电活动受到抑制，表现为抑制期延长和快速振荡频率降低。在小肠中，只有回肠活动发生了显著变化。前列腺素F2α引起该节段II期或不规则尖峰活动增加以及移行性肌电复合波间隔增加。
