State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Strait Collaborative Innovation Center of Biomedicine and Pharmaceutics, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China.
Liuzhou Center for Disease Control and Prevention, Liuzhou, 545007, Guangxi, China.
Int J Cancer. 2018 Mar 15;142(6):1244-1251. doi: 10.1002/ijc.31128. Epub 2017 Nov 17.
Human papillomavirus (HPV) infection is the pathogenesis of anogenital cancers and genital warts in both men and women, whereas there is a scarcity of large studies focused on HPV prevalence in different anogenital sites of both sexes in the same population. From May to July 2014, 2,309 men and 2,378 women aged 18-55 were enrolled from communities in Liuzhou, China. Penis/glans penis/coronary sulcus (PGC) and perianal/anal canal (PA) specimens of men, and vaginal (VA), vulvar (VU) and PA specimens of women, were collected and genotyped for HPV. The prevalence of any HPV tested in PGC and PA samples from men and VA, VU and PA samples from women was 10.8%, 3.8%, 14.2%, 13.3% and 8.4%, respectively. The concordance of VA and VU was highest (kappa = 0.74), followed by VU and PA (0.44), VA and PA (0.38) and PGC and PA (0.14). Besides sex behavior, ever having used a towel supplied by a hotel was a risk factor for both external genital and PA HPV infection. Our data indicated that women were more of a major reservoir for oncogenic HPV infection of both genital sites and PA sites than was men. In both sexes, the genital sites were more likely than PA sites to harbor HPV infection. The concordance rates of HPV infection between genital sites and PA infection were poor.
人乳头瘤病毒（HPV）感染是男性和女性肛门生殖器癌和生殖器疣的发病机制，而针对同一人群中不同性别肛门生殖器部位 HPV 流行率的大型研究较少。2014 年 5 月至 7 月，在中国柳州的社区招募了 2309 名 18-55 岁的男性和 2378 名女性。采集男性的阴茎/龟头/冠状沟（PGC）和肛周/肛门内（PA）标本，以及女性的阴道（VA）、外阴（VU）和 PA 标本，对 HPV 进行基因分型。男性的 PGC 和 PA 样本以及女性的 VA、VU 和 PA 样本中任何 HPV 检测的流行率分别为 10.8%、3.8%、14.2%、13.3%和 8.4%。VA 和 VU 的一致性最高（kappa=0.74），其次是 VU 和 PA（0.44）、VA 和 PA（0.38）和 PGC 和 PA（0.14）。除性行为外，曾使用酒店提供的毛巾也是外阴和 PA HPV 感染的危险因素。我们的数据表明，女性比男性更有可能成为两个生殖器部位和 PA 部位的致癌 HPV 感染的主要储存库。在两性中，生殖器部位比 PA 部位更容易感染 HPV。生殖器部位和 PA 部位 HPV 感染的一致性较差。
