State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Strait Collaborative Innovation Center of Biomedicine and Pharmaceutics, School of Public Health, Xiamen University, Xiamen 361102, Fujian, China.
Liuzhou Center for Disease Control and Prevention, Liuzhou 545027, Guangxi, China.
Emerg Microbes Infect. 2016 Nov 23;5(11):e119. doi: 10.1038/emi.2016.118.
Oncogenic human papillomavirus (HPV) infection is a cause of many anogenital cancers in women and men; however, there is little research on HPV prevalence and risk factors that includes both women and men from the same population. A total of 4687 participants, including 2378 women and 2309 men aged 18-55 years old from the same community, were enrolled in the study in Liuzhou, China. Exfoliated cells were collected from the participants from different anatomic sites and were tested for 13 oncogenic and 3 non-oncogenic HPV types. The prevalence of any oncogenic HPV type was higher in women than in men (18.7% vs 9.4%, P<0.001), whereas the prevalence of HPV 6 and 11 infection was similar (1.4% vs 1.2%, P=0.6832). HPV 52, 58, 16, 39 and 18 were the five most prevalent types in both sexes. Sexual and hygienic behaviors were associated with HPV infection in both women and men. We found that oncogenic HPV DNA detection is more prevalent in women than in men in China, whereas the prevalence of HPV 6 and 11 is similar in both sexes. The data indicate that the interaction of host and virus might be different among high- and low-risk HPV types.
人乳头瘤病毒（HPV）感染是导致女性和男性多种肛门生殖器癌症的原因之一；然而，对于同时包括女性和男性的 HPV 流行率和危险因素研究甚少。共有 4687 名参与者，包括来自中国柳州市同一社区的 2378 名女性和 2309 名 18-55 岁的男性，参与了这项研究。从不同解剖部位采集脱落细胞，检测 13 种致癌型和 3 种非致癌型 HPV 类型。任何致癌型 HPV 类型的流行率在女性中均高于男性（18.7%比 9.4%，P<0.001），而 HPV 6 和 11 感染的流行率相似（1.4%比 1.2%，P=0.6832）。HPV 52、58、16、39 和 18 是两性中最常见的五种类型。性行为和卫生习惯与女性和男性的 HPV 感染有关。我们发现，在中国，致癌型 HPV DNA 检测在女性中的流行率高于男性，而 HPV 6 和 11 的流行率在两性中相似。这些数据表明，高危型和低危型 HPV 之间宿主和病毒的相互作用可能不同。
