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1 型糖尿病患儿动脉粥样硬化早期的 HLA、感染和炎症。

HLA, infections and inflammation in early stages of atherosclerosis in children with type 1 diabetes.

机构信息

Department of Paediatric Cardiology, Paediatric Heart Center, Lund University and Skåne University Hospital, 22185, Lund, Sweden.

Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.

出版信息

Acta Diabetol. 2018 Jan;55(1):41-47. doi: 10.1007/s00592-017-1063-1. Epub 2017 Oct 24.

DOI:10.1007/s00592-017-1063-1
PMID:29064046
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5794827/
Abstract

AIMS

This prospective study focuses on risk factors for arterial damage in children with type 1 diabetes (T1D).

METHODS

Eighty children and adolescents with T1D were investigated twice, approximately 2 years apart, for carotid artery intima-media thickness (cIMT) and compliance (CAC), flow-mediated dilatation (FMD) of the brachial artery, and plasma levels of matrix metalloproteinase (MMP)-8. All subjects were genotyped for HLA. The number of respiratory tract infections (RTI) during the past year was obtained by a questionnaire in 56 patients.

RESULTS

cIMT progression, defined as percentage (%) change of cIMT from baseline, correlated inversely with the % changes of both CAC (p = 0.04, r = - 0.3; n = 62) and FMD (p = 0.03, r = - 0.3; n = 47). In multivariate analysis, RTI frequency correlated significantly with cIMT progression irrespective of age, diabetes duration, BMI, and HbA1c (p = 0.03, r = 0.3). When patients were divided in relation to RTI, the association of DQ2/8 with cIMT progression remained significant in patients with over three infections/year (p = 0.04, r = 0.3). During follow-up, the group of DQ2/8 patients with hsCRP > 1 mg/l showed significantly higher levels of plasma MMP-8 than the non-DQ2/8 group.

CONCLUSIONS

The diabetes-risk genotype DQ2/8 and systemic inflammation contribute to pro-atherosclerotic vascular changes in children and adolescents with T1D.

摘要

目的

本前瞻性研究关注的是 1 型糖尿病（T1D）患儿动脉损伤的危险因素。

方法

对 80 名儿童和青少年 T1D 患者进行了两次调查，两次间隔约 2 年，以检测颈动脉内膜中层厚度（cIMT）和顺应性（CAC）、肱动脉血流介导的扩张（FMD）以及基质金属蛋白酶（MMP）-8 的血浆水平。所有受试者均进行了 HLA 基因分型。通过问卷调查获得了 56 名患者过去一年的呼吸道感染（RTI）次数。

结果

cIMT 进展（定义为 cIMT 从基线的百分比变化）与 CAC（p=0.04，r=-0.3；n=62）和 FMD（p=0.03，r=-0.3；n=47）的变化呈负相关。在多变量分析中，RTI 频率与 cIMT 进展显著相关，与年龄、糖尿病病程、BMI 和 HbA1c 无关（p=0.03，r=0.3）。当根据 RTI 将患者分组时，在每年感染超过 3 次的患者中，DQ2/8 与 cIMT 进展的相关性仍然显著（p=0.04，r=0.3）。在随访期间，hsCRP>1mg/l 的 DQ2/8 患者组的血浆 MMP-8 水平显著高于非 DQ2/8 组。

结论

糖尿病风险基因型 DQ2/8 和全身炎症导致 T1D 患儿发生动脉粥样硬化血管变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72f/5794827/1236263bf78a/592_2017_1063_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72f/5794827/31700991d300/592_2017_1063_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72f/5794827/76c426b0f6af/592_2017_1063_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72f/5794827/1911e8f6ccf3/592_2017_1063_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72f/5794827/e8c36ac55efd/592_2017_1063_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72f/5794827/1236263bf78a/592_2017_1063_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72f/5794827/31700991d300/592_2017_1063_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72f/5794827/76c426b0f6af/592_2017_1063_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72f/5794827/1911e8f6ccf3/592_2017_1063_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72f/5794827/e8c36ac55efd/592_2017_1063_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72f/5794827/1236263bf78a/592_2017_1063_Fig5_HTML.jpg

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2
A systematic literature review of the effect of carotid atherosclerosis on local vessel stiffness and elasticity.一项关于颈动脉粥样硬化对局部血管硬度和弹性影响的系统文献综述。
Atherosclerosis. 2015 Nov;243(1):211-22. doi: 10.1016/j.atherosclerosis.2015.09.008. Epub 2015 Sep 8.
3
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Clin Exp Dent Res. 2021 Oct;7(5):833-839. doi: 10.1002/cre2.419. Epub 2021 Aug 27.
4
The Impact of Diabetes Mellitus on Cardiovascular Risk Onset in Children and Adolescents.糖尿病对儿童和青少年心血管风险发病的影响。
Int J Mol Sci. 2020 Jul 12;21(14):4928. doi: 10.3390/ijms21144928.
5
The early detection of atherosclerosis in type 1 diabetes: why, how and what to do about it.1型糖尿病中动脉粥样硬化的早期检测：为何、如何以及如何应对。
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6
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Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):2045-51. doi: 10.1161/ATVBAHA.108.179705.
4
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