导致肥胖及相关疾病的内分泌干扰物。
Endocrine Disruptors Leading to Obesity and Related Diseases.
作者信息
Petrakis Demetrios, Vassilopoulou Loukia, Mamoulakis Charalampos, Psycharakis Christos, Anifantaki Aliki, Sifakis Stavros, Docea Anca Oana, Tsiaoussis John, Makrigiannakis Antonios, Tsatsakis Aristides M
机构信息
Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, 71003 Heraklion, Crete, Greece.
Department of Urology, University General Hospital of Heraklion, Medical School, University of Crete, 71003 Heraklion, Crete, Greece.
出版信息
Int J Environ Res Public Health. 2017 Oct 24;14(10):1282. doi: 10.3390/ijerph14101282.
The review aims to comprehensively present the impact of exposure to endocrine disruptors (EDs) in relation to the clinical manifestation of obesity and related diseases, including diabetes mellitus, metabolic syndrome, cardiovascular diseases, carcinogenesis and infertility. EDs are strong participants in the obesity epidemic scenery by interfering with cellular morphological and biochemical processes; by inducing inflammatory responses; and by presenting transcriptional and oncogenic activity. Obesity and lipotoxicity enhancement occur through reprogramming and/or remodeling of germline epigenome by exposure to EDs. Specific population groups are vulnerable to ED exposure due to current dietary and environmental conditions. Obesity, morbidity and carcinogenicity induced by ED exposure are an evolving reality. Therefore, a new collective strategic approach is deemed essential, for the reappraisal of current global conditions pertaining to energy management.
本综述旨在全面阐述接触内分泌干扰物（EDs）与肥胖及相关疾病（包括糖尿病、代谢综合征、心血管疾病、致癌作用和不孕症）临床表现之间的关系。EDs通过干扰细胞形态和生化过程、诱导炎症反应以及表现出转录和致癌活性，在肥胖流行情况中起着重要作用。接触EDs会通过生殖系表观基因组的重编程和/或重塑导致肥胖和脂毒性增强。由于当前的饮食和环境状况，特定人群更容易受到EDs暴露的影响。EDs暴露引起的肥胖、发病率和致癌性是一个不断发展的现实。因此，重新评估当前与能源管理相关的全球状况，一种新的集体战略方法被认为至关重要。
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