School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology (QUT), 2 George Street, QLD, 4000, Brisbane, Australia.
Macromolecular Architectures, Institut für Technische Chemie und Polymerchemie, Karlsruhe Institute of Technology (KIT), Engesserstrasse 18, 76131, Karlsruhe, Germany.
Angew Chem Int Ed Engl. 2018 Feb 19;57(8):2036-2045. doi: 10.1002/anie.201709991. Epub 2018 Jan 16.
Chemical reactions are classically controlled by the judicious choice of functional groups as well as external factors such as temperature and catalysts. However, the use of light-induced reactions not only offers precise temporal and spatial control, but critically allows highly specific reaction channels to be selectively addressed through wavelength and intensity, thereby enabling targeted covalent bonds to be made and broken. Photoreversible cycloadditions are the most promising candidates to seize the outlined potential upon selective cyclization and cycloreversion, but are today still far from fulfilling these expectations. The current Minireview critically explores the current challenges in the application of photoreversible cycloadditions and discusses the steps necessary to realize their potential in molecular biology, biomimetic systems, 3D laser lithographic processes, and advanced soft matter materials with reprogrammable and self-healing properties.
化学反应通常通过明智地选择官能团以及温度和催化剂等外部因素来控制。然而，利用光诱导反应不仅提供了精确的时空控制，而且关键是可以通过波长和强度选择性地处理高度特定的反应通道，从而能够选择性地形成和断裂靶向共价键。光致可逆环加成是在选择性环化和环还原时抓住上述潜力的最有前途的候选者，但目前仍远未达到这些预期。本综述批判性地探讨了在光致可逆环加成应用中当前面临的挑战，并讨论了实现其在分子生物学、仿生系统、3D 激光光刻工艺以及具有可编程和自修复特性的先进软物质材料中的潜力所需的步骤。
