Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstraße 2, 37077, Göttingen, Germany.
Angew Chem Int Ed Engl. 2017 Dec 11;56(50):15891-15895. doi: 10.1002/anie.201709087. Epub 2017 Nov 22.
A unified strategy for nickel(0)-catalyzed C-H allylations, alkenylations, and dienylations has been realized through versatile hydroarylations of allenes with ample scope. Thus, an inexpensive nickel catalyst modified with a N-heterocyclic carbene ligand enabled the direct transformation of C-H bonds of biologically relevant imidazole and purine derivatives with full control of regio- and chemoselectivity.
通过各种烯丙基与富电子芳基的氢芳基化反应，实现了镍(0)催化的 C-H 烯丙基化、烯基化和二烯基化的统一策略。因此，一种廉价的镍催化剂，用 N-杂环卡宾配体进行修饰，使具有生物相关性的咪唑和嘌呤衍生物的 C-H 键能够直接转化，并具有完全的区域和化学选择性控制。
