基于激光的水凝胶降解基础及其在细胞和组织工程中的应用。
Fundamentals of Laser-Based Hydrogel Degradation and Applications in Cell and Tissue Engineering.
机构信息
Department of Biomedical Engineering, University of Delaware, 150 Academy Street, 161 Colburn Lab, Newark, DE, 19716, USA.
Delaware Biotechnology Institute, 15 Innovation Way, Newark, DE, 19711, USA.
出版信息
Adv Healthc Mater. 2017 Dec;6(24). doi: 10.1002/adhm.201700681. Epub 2017 Oct 24.
Abstract
The cell and tissue engineering fields have profited immensely through the implementation of highly structured biomaterials. The development and implementation of advanced biofabrication techniques have established new avenues for generating biomimetic scaffolds for a multitude of cell and tissue engineering applications. Among these, laser-based degradation of biomaterials is implemented to achieve user-directed features and functionalities within biomimetic scaffolds. This review offers an overview of the physical mechanisms that govern laser-material interactions and specifically, laser-hydrogel interactions. The influences of both laser and material properties on efficient, high-resolution hydrogel degradation are discussed and the current application space in cell and tissue engineering is reviewed. This review aims to acquaint readers with the capability and uses of laser-based degradation of biomaterials, so that it may be easily and widely adopted.
摘要
细胞和组织工程领域通过实施高度结构化的生物材料受益匪浅。先进的生物制造技术的发展和实施为多种细胞和组织工程应用中仿生支架的生成开辟了新途径。其中，基于激光的生物材料降解被用于实现仿生支架内的用户导向特征和功能。本综述概述了控制激光-材料相互作用的物理机制，特别是激光-水凝胶相互作用。讨论了激光和材料特性对高效、高分辨率水凝胶降解的影响，并回顾了细胞和组织工程中的当前应用领域。本综述旨在使读者了解基于激光的生物材料降解的能力和用途，以便能够轻松且广泛地采用。
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