Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen H4032, Hungary.
Department of Internal Medicine, Building C, Faculty of Medicine, University of Debrecen, Debrecen H4032, Hungary.
Molecules. 2017 Oct 21;22(10):1782. doi: 10.3390/molecules22101782.
Among diabetes patients, ophthalmological complications are very frequent. High blood glucose and (consequential) ischemia-reperfusion (I/R) injury contribute significantly to the severity of retinopathies. Diabetic retinopathy is among the leading causes of blindness. Our study demonstrates the effect of sour cherry seed extract (SCSE) on blood glucose and function of the retina with electroretinography (ERG) in a diabetic setting with or without ischemia-reperfusion (I/R) injury in Zucker Diabetic Fatty (ZDF) rats. Our results prove that the SCSE has a retinoprotective effect in diabetic rats: according to ERG measurements, SCSE treatment mitigated the retinal function-damaging effect of diabetes, and proved to be protective in the diabetic eye against ischemia-reperfusion injuries of the retina. Outcomes suggest that the protective effects of SCSE may occur through several pathways, including HO-1 dependent mechanisms. The observation that SCSE treatment decreases blood glucose is also novel. These findings offer the possibility for development of novel therapeutic strategies utilizing this emerging functional food, in particular in the prevention of conditions resulting from high blood glucose or I/R injury, such as deterioration of retinal microcirculation.
在糖尿病患者中，眼科并发症非常常见。高血糖和（随之而来的）缺血再灌注（I/R）损伤显著加重了视网膜病变的严重程度。糖尿病性视网膜病变是导致失明的主要原因之一。我们的研究证明了酸樱桃籽提取物（SCSE）在伴有或不伴有缺血再灌注（I/R）损伤的糖尿病环境中对 Zucker 糖尿病肥胖（ZDF）大鼠的血糖和视网膜功能（通过视网膜电图（ERG））的影响。我们的结果证明了 SCSE 对糖尿病大鼠具有视网膜保护作用：根据 ERG 测量，SCSE 治疗减轻了糖尿病对视网膜功能的损害作用，并被证明对糖尿病眼具有抗视网膜缺血再灌注损伤的保护作用。结果表明，SCSE 的保护作用可能通过多种途径发生，包括 HO-1 依赖性机制。观察到 SCSE 治疗可降低血糖，这也是新颖的发现。这些发现为利用这种新兴功能性食品开发新的治疗策略提供了可能性，特别是在预防因高血糖或 I/R 损伤引起的疾病方面，例如视网膜微循环恶化。
