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步行速度并非评估机器人辅助步态训练对运动不完全性脊髓损伤患者疗效的最佳指标:一项荟萃分析的系统评价

Walking speed is not the best outcome to evaluate the effect of robotic assisted gait training in people with motor incomplete Spinal Cord Injury: A Systematic Review with meta-analysis.

作者信息

Aguirre-Güemez Ana Valeria, Pérez-Sanpablo Aberto Isaac, Quinzaños-Fresnedo Jimena, Pérez-Zavala Ramiro, Barrera-Ortiz Aída

机构信息

a División de Rehabilitación Neurológica , Instituto Nacional de Rehabilitación , Ciudad de México , México.

b Laboratorio de análisis de movimiento , Instituto Nacional de Rehabilitación , Ciudad de México , México.

出版信息

J Spinal Cord Med. 2019 Mar;42(2):142-154. doi: 10.1080/10790268.2017.1390644. Epub 2017 Oct 25.

Abstract

CONTEXT

While there are previous systematic reviews on the effectiveness of the use of robotic-assisted gait training (RAGT) in people with spinal cord injuries (SCI), as this is a dynamic field, new studies have been produced that are now incorporated on this systematic review (SR) with meta-analysis, updating the available evidence on this area.

OBJECTIVE

To synthesise the available evidence on the use of RAGT, to improve gait, strength and functioning.

METHODS

SR and meta-analysis following the Cochrane Handbook for Systematic Reviews of Interventions were implemented. Cochrane Injuries Group Specialized Register, PubMed, MEDLINE, EMBASE, CINAHL, ISIWeb of Science (SCIEXPANDED) databases were reviewed for the period 1990 to December 2016. Three researchers independently identified and categorized trials; 293 studies were identified, 273 eliminated; remaining 15 randomized clinical trials (RCT) and five SR. Six studies had available data for meta-analysis (222 participants).

RESULTS

The pooled mean demonstrated a beneficial effect of RAGT for WISCI, FIM-L and LEMS (3.01, 2.74 and 1.95 respectively), and no effect for speed.

CONCLUSIONS

The results show a positive effect in the use of RAGT. However, this should be taken carefully due to heterogeneity of the studies, small samples and identified limitations of some of the included trials. These results highlight the relevance of implementing a well-designed multicenter RCT powered enough to evaluate different RAGT approaches.

摘要

背景

虽然之前已有关于脊髓损伤(SCI)患者使用机器人辅助步态训练(RAGT)有效性的系统评价,但由于该领域发展迅速,已有新的研究成果,现纳入本系统评价(SR)并进行荟萃分析,以更新该领域的现有证据。

目的

综合关于使用RAGT改善步态、力量和功能的现有证据。

方法

按照Cochrane干预措施系统评价手册进行系统评价和荟萃分析。检索了1990年至2016年12月期间的Cochrane损伤组专业注册库、PubMed、MEDLINE、EMBASE、CINAHL、ISI科学网(SCIEXPANDED)数据库。三名研究人员独立识别并分类试验;共识别出293项研究,排除273项;其余15项随机临床试验(RCT)和5项系统评价。六项研究有可用于荟萃分析的数据(222名参与者)。

结果

汇总均值显示RAGT对脊髓损伤步行指数(WISCI)、功能独立性测量量表-下肢部分(FIM-L)和四肢肌力评分(LEMS)有有益影响(分别为3.01、2.74和1.95),对速度无影响。

结论

结果显示使用RAGT有积极效果。然而,由于研究的异质性、样本量小以及部分纳入试验存在局限性,应谨慎看待这一结果。这些结果凸显了开展一项设计良好、样本量充足的多中心随机对照试验以评估不同RAGT方法的重要性。

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