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[物种名称]次生代谢产物的结构与生物活性

Structures and Biological Activities of Secondary Metabolites from spp.

作者信息

Chen Weikang, Yu Miao, Chen Shiji, Gong Tianmi, Xie Linlin, Liu Jinqin, Bian Chang, Huang Guolei, Zheng Caijuan

机构信息

Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China.

Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou 571158, China.

出版信息

J Fungi (Basel). 2024 Feb 29;10(3):190. doi: 10.3390/jof10030190.

DOI:10.3390/jof10030190
PMID:38535199
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10971283/
Abstract

The fungus genus is an important source of drug discoveries in scientific fields and in the pharmaceutical industry due to its potential to produce a variety of structured novel and bioactive secondary metabolites. This review prioritizes the structures of the secondary metabolites of spp. from 1994 to January 2024 and their relevant biological activities. A total of 445 new compounds, including terpenoids, nitrogen-containing compounds, polyketides, lactones, and other classes, are presented in this review. Remarkably, among these compounds, 177 compounds show various biological activities, including cytotoxic, antimicrobial, anti-inflammatory, antifungal, immunosuppressive, and enzyme-inhibitory activities. This paper will guide further investigations into the structures of novel and potent active natural products derived from and their potential contributions to the future development of new natural drug products in the agricultural and medicinal fields.

摘要

由于真菌属有潜力产生多种结构新颖且具有生物活性的次生代谢产物，因此它是科学领域和制药行业中药物发现的重要来源。本综述重点关注了1994年至2024年1月期间该属真菌次生代谢产物的结构及其相关生物活性。本综述共介绍了445种新化合物，包括萜类化合物、含氮化合物、聚酮化合物、内酯及其他类别。值得注意的是，在这些化合物中，有177种化合物具有多种生物活性，包括细胞毒性、抗菌、抗炎、抗真菌、免疫抑制和酶抑制活性。本文将为进一步研究该属真菌衍生的新型高效活性天然产物的结构及其对农业和医药领域新型天然药物产品未来发展的潜在贡献提供指导。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/652d/10971283/8ae8b525635b/jof-10-00190-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/652d/10971283/2b508b1cebaf/jof-10-00190-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/652d/10971283/47a482b36e15/jof-10-00190-g002a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/652d/10971283/7f310c16a06a/jof-10-00190-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/652d/10971283/ff742341973b/jof-10-00190-g004a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/652d/10971283/12fc1d7212f2/jof-10-00190-g005a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/652d/10971283/714b080af9b4/jof-10-00190-g006a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/652d/10971283/1bc06e9df1c8/jof-10-00190-g007a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/652d/10971283/11a10955feca/jof-10-00190-g008a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/652d/10971283/8ae8b525635b/jof-10-00190-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/652d/10971283/2b508b1cebaf/jof-10-00190-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/652d/10971283/47a482b36e15/jof-10-00190-g002a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/652d/10971283/7f310c16a06a/jof-10-00190-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/652d/10971283/ff742341973b/jof-10-00190-g004a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/652d/10971283/12fc1d7212f2/jof-10-00190-g005a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/652d/10971283/714b080af9b4/jof-10-00190-g006a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/652d/10971283/1bc06e9df1c8/jof-10-00190-g007a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/652d/10971283/11a10955feca/jof-10-00190-g008a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/652d/10971283/8ae8b525635b/jof-10-00190-g009.jpg

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