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药剂师与精神科医生协作式患者教育对双相情感障碍(BPAD)患者药物依从性和生活质量(QOL)的影响

Impact of Pharmacist-Psychiatrist Collaborative Patient Education on Medication Adherence and Quality of Life (QOL) of Bipolar Affective Disorder (BPAD) Patients.

作者信息

Mishra Ambed, Krishna Gudi S, Alla Sravani, Kurian Tony D, Kurian Justin, Ramesh Madhan, Kishor M

机构信息

Department of Pharmacy Practice, JSS College of Pharmacy, Jagadguru Sri Shivarathreeshwara University, Mysore, India.

Department of Psychiatry, JSS Hospital, Mysore, India.

出版信息

Front Pharmacol. 2017 Oct 10;8:722. doi: 10.3389/fphar.2017.00722. eCollection 2017.

DOI:10.3389/fphar.2017.00722
PMID:29066976
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5641349/
Abstract

Bipolar Affective Disorder (BPAD) is one of the leading causes of disability globally. Medication non-adherence and low quality of life (QOL) are the major challenges associated with the treatment of BPAD patients. Aim of this study was to assess the impact of pharmacist-psychiatrist collaborative patient education on medication adherence and QOL of BPAD patients. A prospective randomized control study was conducted in the psychiatry outpatient department in a tertiary care setting. The eligible patients were enrolled and randomized into test (collaborative care) and control (usual care) groups. Patient education was provided by pharmacists to the test group patients, along with the usual care provided to all the patients. Patients were followed for three follow-ups of nearly 1 month intervals. Medication adherence and QOL were assessed by Medication Adherence Rating Scale and WHOQOL-BREF questionnaire, respectively. -test was used and -values < 0.05 were considered statistically significant. Out of 75 patients enrolled, 73 patients were followed for all the three follow-ups and completed the study. Thirty-eight patients belonged to test and 35 were in control group. The mean age of patients was 34.21 ± 10.91 years. Forty-eight (65.75%) patients belonged to age group of 18-39 years. There were 41 males (56.16%) and 32 female patients (43.83%) in the study. Mean improvement in medication adherence and QOL of the test and control groups were found to be 2.06 ± 0.15 (<0.001) and 13.8 ± 10.5 (<0.05), respectively. This study concluded that pharmacist-psychiatrist collaborative patient education can significantly improve the medication adherence and QOL of the BPAD patients. Statistically significant results indicating improved patient care and outcomes were possible when pharmacists worked as a team with psychiatrists.

摘要

双相情感障碍(BPAD)是全球致残的主要原因之一。药物治疗依从性差和生活质量(QOL)低是双相情感障碍患者治疗面临的主要挑战。本研究的目的是评估药剂师 - 精神科医生协作式患者教育对双相情感障碍患者药物治疗依从性和生活质量的影响。在三级医疗环境的精神科门诊部进行了一项前瞻性随机对照研究。符合条件的患者被纳入并随机分为试验组(协作护理)和对照组(常规护理)。药剂师为试验组患者提供患者教育,同时为所有患者提供常规护理。对患者进行了三次随访,间隔时间近1个月。分别通过药物治疗依从性评定量表和世界卫生组织生活质量简表(WHOQOL - BREF)问卷评估药物治疗依从性和生活质量。使用t检验,P值<0.05被认为具有统计学意义。在纳入的75例患者中,73例患者完成了所有三次随访并完成了研究。38例患者属于试验组,35例属于对照组。患者的平均年龄为34.21±10.91岁。48例(65.75%)患者属于18 - 39岁年龄组。研究中有41例男性(56.16%)和32例女性患者(43.83%)。试验组和对照组在药物治疗依从性和生活质量方面的平均改善分别为2.06±0.15(P<0.001)和13.8±10.5(P<0.05)。本研究得出结论,药剂师 - 精神科医生协作式患者教育可显著提高双相情感障碍患者的药物治疗依从性和生活质量。当药剂师与精神科医生团队合作时,有统计学意义的结果表明可以改善患者护理和治疗效果。