Mishra Ambed, Kishor Manohar Rao, Ramesh Madhan
Department of Community Medicine, JSS Medical College and Hospital, JSS Academy of Higher Education & Research, Mysore, Karnataka, India.
Department of Psychiatry, JSS Medical College and Hospital, JSS Academy of Higher Education & Research, Mysore, Karnataka, India.
Front Psychiatry. 2025 Feb 25;16:1499893. doi: 10.3389/fpsyt.2025.1499893. eCollection 2025.
Depression is a common but severe mental health disorder affecting individuals globally. Medication non-adherence and low health-related quality of life (HRQoL) are the major challenges associated with the treatment of patients with depression.
A prospective Randomized Controlled Trial (RCT) was conducted in the psychiatry outpatient department of a tertiary care hospital for six months. Patients were assigned to either a control group receiving usual care or a test group receiving collaborative care using simple randomization technique. The eligible patients diagnosed with depression were enrolled and the data were collected from patient's care records, prescriptions, patient interviews, patient representatives and healthcare professionals. The intervention in the test group consisted of comprehensive patient education, including a thorough counseling session with a research clinical pharmacist. Counseling sessions included information on the disease, medications prescribed, possible side effects, compliance with medications and overall treatment. The data collected from both patient groups was analyzed for medication adherence using the Medication Adherence Rating Scale (MARS) and health-related quality of life (HRQoL) using the WHOQOL-BREF questionnaire. Statistical analyses were performed using a student t-test with a significance level of P value < 0.05.
The collaborative care group showed a statistically significant improvement in medication adherence, with a mean increase of 1.67 ± 0.25 (P < 0.001), compared with a mean increase of 0.69 ± 0.05 (P < 0.05) for the usual care group. Similarly, HRQoL scores also improved significantly more in the collaborative care group, with a mean increase of 28.01 ± 2.05 (P < 0.001), compared with a mean increase of 12.46 ± 0.26 (P < 0.05) for the usual care group.
This study concluded that pharmacist-psychiatrist collaborative patient education can significantly improve the medication adherence and HRQoL of the patients with depression. Statistically significant increases in medication adherence and HRQoL were observed in the collaborative group.
抑郁症是一种常见但严重的心理健康障碍，影响着全球各地的个人。药物治疗依从性差和健康相关生活质量（HRQoL）低是抑郁症患者治疗面临的主要挑战。
在一家三级护理医院的精神科门诊部进行了一项为期六个月的前瞻性随机对照试验（RCT）。使用简单随机化技术将患者分配到接受常规护理的对照组或接受协作护理的试验组。纳入诊断为抑郁症的合格患者，并从患者护理记录、处方、患者访谈、患者代表和医疗保健专业人员处收集数据。试验组的干预措施包括全面的患者教育，包括与研究临床药剂师进行深入的咨询会议。咨询会议包括有关疾病、所开药物、可能的副作用、药物依从性和整体治疗的信息。使用药物依从性评定量表（MARS）分析从两个患者组收集的数据的药物依从性，并使用世界卫生组织生活质量简表（WHOQOL-BREF）问卷分析健康相关生活质量（HRQoL）。使用学生t检验进行统计分析，显著性水平为P值<0.05。
协作护理组在药物依从性方面显示出统计学上的显著改善，平均增加1.67±0.25（P<0.001），而常规护理组平均增加0.69±0.05（P<0.05）。同样，协作护理组的HRQoL得分也显著提高，平均增加28.01±2.05（P<0.001），而常规护理组平均增加12.46±0.26（P<0.05）。
本研究得出结论，药剂师 - 精神科医生协作的患者教育可以显著提高抑郁症患者的药物依从性和HRQoL。协作组在药物依从性和HRQoL方面观察到统计学上的显著增加。
