Singh Sandev, Loo Larry Ee Juan, Watters Christopher, Ahmed Suhail
Department of Gastroenterology, University Hospital Aintree, Liverpool, UK.
Frontline Gastroenterol. 2017 Oct;8(4):232-235. doi: 10.1136/flgastro-2016-100760. Epub 2017 Jan 19.
Collagenous panenteritis is a rare inflammatory condition that causes profound diarrhoea and weight loss. There has only been a handful of cases reported in the literature. We report this rare case and the diagnostic difficulties encountered in securing the diagnosis. A 59-year-old woman presented with an 8-month history of diarrhoea and weight loss on a background of a family history of coeliac disease. Her presentation was complicated with acute kidney injury secondary to prerenal losses. Repeated gastroscopies and colonoscopies along with biopsies were inconclusive. It was not until histology of biopsies taken at endoscopies were reviewed that a diagnosis of collagenous panenteritis was secured. Her management revolved around combination of budesonide, gluten-free diet and antidiarrhoeals, which has achieved clinical remission.
胶原性全肠炎是一种罕见的炎症性疾病，可导致严重腹泻和体重减轻。文献中仅报道过少数病例。我们报告这一罕见病例以及确诊过程中遇到的诊断困难。一名59岁女性，有8个月腹泻和体重减轻病史，家族中有乳糜泻病史。她的病情因肾前性失液继发急性肾损伤而复杂化。多次胃镜和结肠镜检查及活检均无定论。直到对内镜检查时所取活检组织进行组织学复查后，才确诊为胶原性全肠炎。她的治疗主要围绕布地奈德、无麸质饮食和止泻药联合使用，目前已实现临床缓解。
