Drobnjak Dragana, Munch Inger Christine, Glümer Charlotte, Færch Kristine, Kessel Line, Larsen Michael, Veiby Nina C B B
Center of Eye Research, Department of Ophthalmology, Oslo University Hospital and University of Oslo, Oslo, Norway.
Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
J Clin Transl Endocrinol. 2017 Mar 21;8:22-28. doi: 10.1016/j.jcte.2017.03.002. eCollection 2017 Jun.
To examine the association between retinal vessel diameters and retinopathy in participants with and without type 2 diabetes in a Danish population-based cohort.
The study included 878 persons aged 30 to 60 years from the Inter99 Eye Study. Retinopathy was defined as a presence of one or more retinal hemorrhages or one or more microaneurysms. Vessel diameters were expressed as central retinal artery equivalent diameter (CRAE) and central retinal vein equivalent diameter (CRVE). Multiple linear regression analyses were performed.
Among participants with diabetes, CRAE was 6.3 µm (CI 95%: 1.0 to 11.6, p = 0.020) wider and CRVE was 7.9 µm (CI 95%: 0.7 to 15.2, p = 0.030) wider in those with retinopathy compared to those without retinopathy, after adjusting for age, gender, HbA1c, blood pressure, smoking, serum total and HDL cholesterol. In all participants, CRAE increased with presence of retinopathy (p = 0.005) and with smoking (p = 0.001), and CRAE decreased with hypertension (p < 0.001), high HDL cholesterol (p = 0.016) and age (p < 0.001). Central retinal vein equivalent diameter increased with presence of retinopathy (p = 0.022) and with smoking (p < 0.001), and decreased with higher HDL cholesterol (p < 0.001) and age (p = 0.015). Female gender was associated with wider CRVE (p = 0.029).
Wider retinal vessel diameters were associated with the presence of retinopathy in participants with diabetes, but not in participants without diabetes. The associations between retinal vessel diameters and known retinopathy risk factors were confirmed. These results suggest that information obtained by non-invasive imaging of the interior of the eye can contribute to a better understanding of systemic disease processes.
在丹麦一项基于人群的队列研究中，探讨2型糖尿病患者和非2型糖尿病患者视网膜血管直径与视网膜病变之间的关联。
该研究纳入了Inter99眼部研究中878名年龄在30至60岁之间的人。视网膜病变定义为存在一处或多处视网膜出血或一处或多处微动脉瘤。血管直径用视网膜中央动脉等效直径（CRAE）和视网膜中央静脉等效直径（CRVE）表示。进行了多元线性回归分析。
在糖尿病患者中，在调整年龄、性别、糖化血红蛋白、血压、吸烟、血清总胆固醇和高密度脂蛋白胆固醇后，与无视网膜病变者相比，有视网膜病变者的CRAE宽6.3μm（95%置信区间：1.0至11.6，p = 0.020），CRVE宽7.9μm（95%置信区间：0.7至15.2，p = 0.030）。在所有参与者中，CRAE随着视网膜病变的存在（p = 0.005）和吸烟（p = 0.001）而增加，随着高血压（p < 0.001）、高HDL胆固醇（p = 0.016）和年龄（p < 0.001）而降低。视网膜中央静脉等效直径随着视网膜病变的存在（p = 0.022）和吸烟（p < 0.001）而增加，随着较高的HDL胆固醇（p < 0.001）和年龄（p = 0.015）而降低。女性与较宽的CRVE相关（p = 0.029）。
较宽的视网膜血管直径与糖尿病患者视网膜病变的存在相关，但与非糖尿病患者无关。视网膜血管直径与已知视网膜病变危险因素之间的关联得到了证实。这些结果表明，通过眼部内部的非侵入性成像获得的信息有助于更好地理解全身疾病过程。
