Wijarnpreecha K, Boonpheng B, Thongprayoon C, Jaruvongvanich V, Ungprasert P
Department of Internal Medicine, Bassett Medical Center, Cooperstown, New York, USA.
Department of Internal Medicine, East Tennessee State University, Johnson City, TN, USA.
J Postgrad Med. 2018 Jan-Mar;64(1):35-39. doi: 10.4103/jpgm.JPGM_319_17.
BACKGROUND/OBJECTIVES: The possible relationship between smoking and risk of colonic diverticulosis has been suggested by recent epidemiological studies, although the results were inconsistent. This meta-analysis was conducted to summarize all available data.
A comprehensive literature review was conducted using the MEDLINE and EMBASE databases through May 2017 to identify all studies that compared the risk of colonic diverticulosis among current and former smokers versus nonsmokers. Effect estimates from each study were extracted and combined together using the random-effect, generic inverse variance method of DerSimonian and Laird.
Of 465 potentially eligible articles, three prospective cohort studies with 130,520 participants met the eligibility criteria and were included in the meta-analysis. The risk of colonic diverticulosis in current smokers was significantly higher than nonsmokers with the pooled risks ratio of 1.46 (95% confidence interval [CI], 1.13-1.89). However, the risk of colonic diverticulosis in former smokers was not significantly higher than nonsmokers with the pooled risk ratio of 1.13 (95% CI, 0.88-1.44).
A significantly increased risk of colonic diverticulosis among current smokers is demonstrated in this study.
背景/目的：近期的流行病学研究提示了吸烟与结肠憩室病风险之间可能存在的关联，尽管结果并不一致。本荟萃分析旨在总结所有可用数据。
通过检索MEDLINE和EMBASE数据库，对截至2017年5月的文献进行全面综述，以识别所有比较当前吸烟者、既往吸烟者与非吸烟者结肠憩室病风险的研究。提取每项研究的效应估计值，并使用DerSimonian和Laird的随机效应、通用逆方差方法进行合并。
在465篇可能符合条件的文章中，三项涉及130,520名参与者的前瞻性队列研究符合纳入标准并被纳入荟萃分析。当前吸烟者患结肠憩室病的风险显著高于非吸烟者，合并风险比为1.46（95%置信区间[CI]，1.13 - 1.89）。然而，既往吸烟者患结肠憩室病的风险并不显著高于非吸烟者，合并风险比为1.13（95%CI，0.88 - 1.44）。
本研究表明当前吸烟者患结肠憩室病的风险显著增加。
