饮食与牛津欧洲癌症前瞻性调查与营养队列（EPIC）中憩室病的风险：英国素食者和非素食者的前瞻性研究。
Diet and risk of diverticular disease in Oxford cohort of European Prospective Investigation into Cancer and Nutrition (EPIC): prospective study of British vegetarians and non-vegetarians.
机构信息
Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, UK.
出版信息
BMJ. 2011 Jul 19;343:d4131. doi: 10.1136/bmj.d4131.
OBJECTIVE
To examine the associations of a vegetarian diet and dietary fibre intake with risk of diverticular disease.
DESIGN
Prospective cohort study.
SETTING
The EPIC-Oxford study, a cohort of mainly health conscious participants recruited from around the United Kingdom.
PARTICIPANTS
47,033 men and women living in England or Scotland of whom 15,459 (33%) reported consuming a vegetarian diet.
MAIN OUTCOME MEASURES
Diet group was assessed at baseline; intake of dietary fibre was estimated from a 130 item validated food frequency questionnaire. Cases of diverticular disease were identified through linkage with hospital records and death certificates. Hazard ratios and 95% confidence intervals for the risk of diverticular disease by diet group and fifths of intake of dietary fibre were estimated with multivariate Cox proportional hazards regression models.
RESULTS
After a mean follow-up time of 11.6 years, there were 812 cases of diverticular disease (806 admissions to hospital and six deaths). After adjustment for confounding variables, vegetarians had a 31% lower risk (relative risk 0.69, 95% confidence interval 0.55 to 0.86) of diverticular disease compared with meat eaters. The cumulative probability of admission to hospital or death from diverticular disease between the ages of 50 and 70 for meat eaters was 4.4% compared with 3.0% for vegetarians. There was also an inverse association with dietary fibre intake; participants in the highest fifth (≥25.5 g/day for women and ≥26.1 g/day for men) had a 41% lower risk (0.59, 0.46 to 0.78; P<0.001 trend) compared with those in the lowest fifth (<14 g/day for both women and men). After mutual adjustment, both a vegetarian diet and a higher intake of fibre were significantly associated with a lower risk of diverticular disease.
CONCLUSIONS
Consuming a vegetarian diet and a high intake of dietary fibre were both associated with a lower risk of admission to hospital or death from diverticular disease.
目的
探讨素食和膳食纤维摄入与憩室病风险的关联。
设计
前瞻性队列研究。
地点
英国各地主要有健康意识的参与者组成的 EPIC-Oxford 研究队列。
参与者
47033 名居住在英格兰或苏格兰的男性和女性，其中 15459 人（33%）报告食用素食。
主要观察指标
饮食组在基线时进行评估；膳食纤维摄入量通过 130 项经验证的食物频率问卷进行估计。通过与医院记录和死亡证明的链接确定憩室病病例。使用多变量 Cox 比例风险回归模型估计按饮食组和膳食纤维摄入量五分位数划分的憩室病风险的风险比和 95%置信区间。
结果
平均随访 11.6 年后，共发生 812 例憩室病（806 例住院和 6 例死亡）。在校正混杂变量后，素食者患憩室病的风险降低了 31%（相对风险 0.69，95%置信区间 0.55 至 0.86）。50 至 70 岁时，肉食者因憩室病住院或死亡的累积概率为 4.4%，而素食者为 3.0%。膳食纤维摄入量也呈负相关；女性最高五分位数（≥25.5 g/天）和男性最高五分位数（≥26.1 g/天）参与者的风险降低了 41%（0.59，0.46 至 0.78；P<0.001 趋势）与最低五分位数（女性和男性均<14 g/天）相比。相互调整后，素食和膳食纤维摄入较高均与憩室病风险降低显著相关。
结论
素食和膳食纤维摄入较高与憩室病住院或死亡风险降低相关。
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