Keyvani Hossein, Moghoofei Mohsen, Bokharaei-Salim Farah, Mostafaei Shayan, Javad Mousavi Seyed-Ali, Monavari Seyed Hamidreza, Esghaei Maryam
Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Department of Microbiology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
J Med Microbiol. 2017 Nov;66(11):1602-1606. doi: 10.1099/jmm.0.000628. Epub 2017 Oct 25.
Idiopathic pulmonary fibrosis (IPF) is a chronic and ultimately fatal lung disease. One of the risk factors involved in the acquisition of IPF is viral infections, especially respiratory viruses. In the present study, we investigated the detection of respiratory viruses and the possible relationship between these viruses and IPF.
This cross-sectional study was supported by the Iran University of Medical Sciences (IUMS), Tehran, Iran. A total of 40 respiratory samples (five nasopharyngeal and 35 bronchoalveolar lavage specimens) were obtained from IPF patients referred to IUMS hospitals between April 2015 and December 2016. Assays were performed using the CLART Pneumovir DNA array assay, which made it possible to detect five genera of respiratory viruses simultaneously.Results/Key findings. Altogether, 22 of the 40 participants were male. Respiratory syncytial virus (RSV), parainfluenza, rhino, corona and influenza viruses were found in 2.5 % (1/40), 7.5 % (3/40), 10 % (4/40), 2.5 % (1/40) and 0% (0/40) of cases, respectively.
Determining a correlation between the viruses and IPF is not an easy task, and therefore, this will require more research. In addition, the CLART Pneumovir DNA array can be considered as a useful method for simultaneous detection of several viral respiratory infections.
特发性肺纤维化（IPF）是一种慢性且最终致命的肺部疾病。感染IPF的危险因素之一是病毒感染，尤其是呼吸道病毒。在本研究中，我们调查了呼吸道病毒的检测情况以及这些病毒与IPF之间可能存在的关系。
这项横断面研究由伊朗德黑兰医科大学（IUMS）资助。2015年4月至2016年12月期间，从转诊至IUMS医院的IPF患者中总共获取了40份呼吸道样本（5份鼻咽样本和35份支气管肺泡灌洗样本）。使用CLART Pneumovir DNA阵列检测法进行检测，该方法能够同时检测五种呼吸道病毒属。结果/主要发现。40名参与者中共有22名男性。呼吸道合胞病毒（RSV）、副流感病毒、鼻病毒、冠状病毒和流感病毒的检出率分别为2.5%（1/40）、7.5%（3/40）、10%（4/40）、2.5%（1/40）和0%（0/40）。
确定病毒与IPF之间的相关性并非易事，因此，这需要更多的研究。此外，CLART Pneumovir DNA阵列可被视为同时检测多种病毒性呼吸道感染的一种有用方法。
