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白藜芦醇载固体脂质纳米粒对人乳腺癌细胞的抗癌作用。

Anticancer Effects of Resveratrol-Loaded Solid Lipid Nanoparticles on Human Breast Cancer Cells.

机构信息

Department of Biotechnology, Bengbu Medical College, Anhui, Bengbu 233030, China.

Clinical Testing and Diagnose Experimental Center, Bengbu Medical College, Anhui, Bengbu 233030, China.

出版信息

Molecules. 2017 Oct 25;22(11):1814. doi: 10.3390/molecules22111814.

DOI:10.3390/molecules22111814
PMID:29068422
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6150230/
Abstract

In this study, resveratrol-loaded solid lipid nanoparticles (Res-SLNs) were successfully designed to treat MDA-MB-231 cells. The Res-SLNs were prepared using emulsification and low-temperature solidification method. The Res-SLNs were spherical, with small size, negative charge, and narrow size distribution. Compared with free resveratrol, the Res-SLNs displayed a superior ability in inhibiting the proliferation of MDA-MB-231 cells. In addition, Res-SLNs exhibited much stronger inhibitory effects on the invasion and migration of MDA-MB-231 cells. Western blot analysis revealed that Res-SLNs could promote the ratio of Bax/Bcl-2 but decreased the expression of cyclinD1 and c-Myc. These results indicate that the Res-SLN may have great potential for breast cancer treatment.

摘要

本研究设计了载白藜芦醇固体脂质纳米粒（Res-SLNs）用于治疗 MDA-MB-231 细胞。Res-SLNs 采用乳化低温固化法制备。Res-SLNs 呈球形，粒径小，带负电荷，粒径分布较窄。与游离白藜芦醇相比，Res-SLNs 表现出更强的抑制 MDA-MB-231 细胞增殖的能力。此外，Res-SLNs 对 MDA-MB-231 细胞的侵袭和迁移具有更强的抑制作用。Western blot 分析表明，Res-SLNs 可以促进 Bax/Bcl-2 比值，但降低 cyclinD1 和 c-Myc 的表达。这些结果表明，Res-SLN 可能具有治疗乳腺癌的巨大潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ab/6150230/6b386eff8761/molecules-22-01814-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ab/6150230/e993274e1f80/molecules-22-01814-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ab/6150230/86a3e5b60ca7/molecules-22-01814-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ab/6150230/b910826dd1ec/molecules-22-01814-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ab/6150230/d060a331ac3b/molecules-22-01814-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ab/6150230/70bf587d7a8c/molecules-22-01814-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ab/6150230/47973ef627d9/molecules-22-01814-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ab/6150230/6b386eff8761/molecules-22-01814-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ab/6150230/e993274e1f80/molecules-22-01814-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ab/6150230/86a3e5b60ca7/molecules-22-01814-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ab/6150230/b910826dd1ec/molecules-22-01814-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ab/6150230/d060a331ac3b/molecules-22-01814-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ab/6150230/70bf587d7a8c/molecules-22-01814-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ab/6150230/47973ef627d9/molecules-22-01814-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ab/6150230/6b386eff8761/molecules-22-01814-g007.jpg

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