Department of Pediatrics Research, Center for Energy Balance in Cancer Prevention and Survivorship, University of Texas MD Anderson Cancer Center, Houston, Texas.
Pediatr Res. 2018 Jan;83(1-1):50-56. doi: 10.1038/pr.2017.225. Epub 2017 Oct 25.
Obesity at diagnosis is a negative prognostic indicator for several pediatric cancers including acute leukemia and bone tumors. Incidence of obesity in children has increased three-fold over the past 2 decades, and causes for this include poor diet, excessive caloric intake, and lack of physical activity, which are collectively referred to as energy balance-related behaviors. Few energy balance interventions have been implemented in pediatric cancer patients during treatment, and here we will probe the rationale for pursuing such studies. The need to modify composition of calories consumed and to identify specific beneficial exercise regimens will be discussed, relative to weight reduction or management.
肥胖症在诊断时是几个儿科癌症的预后不良指标，包括急性白血病和骨肿瘤。在过去的 20 年中，儿童肥胖症的发病率增加了三倍，其原因包括不良的饮食、过多的热量摄入以及缺乏体力活动，这些都被统称为与能量平衡相关的行为。在治疗期间，很少有能量平衡干预措施在儿科癌症患者中实施，在这里我们将探讨进行此类研究的基本原理。将讨论与体重减轻或管理相关的需要改变消耗的卡路里组成和确定具体有益的运动方案。
