Department of Bioengineering, Clemson University, Clemson, South Carolina.
Institute for Biological Interfaces of Engineering, Clemson University, Clemson, South Carolina.
J Biomed Mater Res B Appl Biomater. 2018 Aug;106(6):2225-2234. doi: 10.1002/jbm.b.34029. Epub 2017 Oct 25.
Despite the relative safety of the procedure, hernia repairs are often associated with chronic post-operative pain. Although this complication has been linked among others to mesh deterioration, details of the processes that lead this deterioration are still unknown. This work aims to bridge this gap by analyzing the chemical, physical and structural alterations in hernia repair meshes exposed to oxidative stress in vitro. Here, we developed a methodology to characterize effect of oxidation stress on structure and properties of polymeric hernia repair meshes. It was shown that structural changes in polypropylene meshes exposed to oxidative stress may involve formation of cross-links between the polymer chains, chain scissions, and hydrogen bonds between the carboxyl groups, which are formed in the material during the oxidation. These effects result in mesh stiffening, ultimately leading to chronic post-operative pain. Moreover, we demonstrated that Composix meshes are more vulnerable to the oxidative stress when compared with UltraPro meshes. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2225-2234, 2018.
尽管该手术相对安全，但疝修补术常伴有慢性术后疼痛。虽然这种并发症与网片劣化等有关，但导致这种劣化的过程细节仍不清楚。本工作旨在通过分析体外氧化应激下疝修补网片的化学、物理和结构变化来填补这一空白。在此，我们开发了一种方法来描述氧化应激对聚合物疝修补网片结构和性能的影响。结果表明，暴露于氧化应激的聚丙烯网片的结构变化可能涉及聚合物链之间形成交联、链断裂以及在材料氧化过程中形成的羧基之间的氢键。这些影响导致网片变硬，最终导致慢性术后疼痛。此外，我们证明与 UltraPro 网片相比，Composix 网片更容易受到氧化应激的影响。 © 2017 Wiley Periodicals, Inc. J 生物材料 Res 部分 B: 应用生物材料, 106B: 2225-2234, 2018.
